Transition-Metal-Free Synthesis of Unsymmetrical Disulfides via Three-Component Reaction of Thiosulfonates, Thiourea and Alkyl halides

被引：11

作者：

Wang, Dungai ^{[1
]}

He, Quan ^{[1
]}

Shi, Keqiang ^{[1
]}

Xiong, Mingteng ^{[1
]}

Zhou, Yifeng ^{[2
]}

Pan, Yuanjiang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

[2] China Jiliang Univ, Coll Life Sci, Hangzhou 310018, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2021年 / 363卷 / 11期

基金：

中国国家自然科学基金;

关键词：

transition-metal-free; unsymmetrical disulfides; one-pot reaction; K2CO3-promoted;

D O I：

10.1002/adsc.202100165

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A transition-metal-free approach to synthesize unsymmetrical disulfides is reported that relies on a K2CO3-promoted one-pot reaction of thiosulfonates, thiourea and alkyl halides under mild conditions. The protocol tolerates a wide range of substrates, leading to various types of unsymmetrical disulfides in moderate to excellent yields. More importantly, the late-stage modification of natural products and drug molecules was also achieved.

引用

页码：2767 / 2772

页数：6

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