Increased expression of pendrin in eosinophilic chronic rhinosinusitis with nasal polyps

被引：11

作者：

Ito, Taku ^{[1
,2
]}

Ikeda, Satoshi ^{[3
]}

Asamori, Tomoaki ^{[2
]}

Honda, Keiji ^{[2
]}

Kawashima, Yoshiyuki ^{[1
]}

Kitamura, Ken ^{[1
]}

Suzuki, Keiko ^{[3
]}

Tsutsumi, Takeshi ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Otolaryngol, Tokyo, Japan

[2] Tsuchiura Kyodo Gen Hosp, Dept Otolaryngol, Tsuchiura, Ibaraki, Japan

[3] Tsuchiura Kyodo Gen Hosp, Pathol, Tsuchiura, Ibaraki, Japan

来源：

BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY | 2019年 / 85卷 / 06期

关键词：

Chronic rhinosinusitis; Pendrin; MUC5AC; Eosinophil; Nasal polyp; ANION TRANSPORTER PENDRIN; SYNDROME GENE; ASTHMA; SLC26A4; CELLS;

D O I：

10.1016/j.bjorl.2018.07.005

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Introduction: Chronic rhinosinusitis with nasal polyps is a heterogeneous disease and appropriate diagnostic algorithms in individual cases are necessary for effective medical treatment. Objective: The purpose of this study was to clarify the relationship between the pendrin expression of nasal polyps and clinical and pathological characteristic features of eosinophilic chronic rhinosinusitis. Methods: A total of 68 patients were classified into eosinophilic chronic rhinosinusitis or non-eosinophilic chronic rhinosinusitis groups according to the degree of eosinophitic infiltration into the nasal polyps. Clinical, hematological, and immunohistochemical analyses were performed and statistically compared between both groups. Results: Thirty-eight were classified into eosinophilic chronic rhinosinusitis and 30 into non-eosinophilic chronic rhinosinusitis groups. There were no significant differences in age distribution, sex ratio, prevalence of asthma, or any other complications between the groups. The mean Lund-Mackay score and the number of serum eosinophits was significantly higher in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis groups. The pendrin expression was more frequently detected in the epithelial surface layer of nasal polyps in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis groups. In addition, mucin 5AC was more widely expressed in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis. Conclusion: Increased expression of pendrin and mucin 5AC in the nasal polyps would be associated with development of eosinophilic chronic rhinosinusitis. This finding could allow the development of a novel therapeutic agent targeted specifically to patients with eosinophilic chronic rhinosinusitis. (C) 2018 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.

引用

页码：760 / 765

页数：6

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