PRODH2-MEDIATED PROLINE METABOLISM BOOSTS CAR T-CELL EFFECTOR FUNCTION

被引:3
作者
不详
机构
关键词
D O I
10.1158/2159-8290.CD-RW2022-054
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Overexpression of PRODH2 augments CAR T-cell proliferation, effector function, and memory phenotype. ©2022 American Association for Cancer Research.
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页码:1405 / 1405
页数:1
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[1]   A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy [J].
Ye, Lupeng ;
Park, Jonathan J. ;
Peng, Lei ;
Yang, Quanjun ;
Chow, Ryan D. ;
Dong, Matthew B. ;
Lam, Stanley Z. ;
Guo, Jianjian ;
Tang, Erting ;
Zhang, Yueqi ;
Wang, Guangchuan ;
Dai, Xiaoyun ;
Du, Yaying ;
Kim, Hyunu R. ;
Cao, Hanbing ;
Errami, Youssef ;
Clark, Paul ;
Bersenev, Alexey ;
Montgomery, Ruth R. ;
Chen, Sidi ;
Montgomery, Ruth R. ;
Chen, Sidi .
CELL METABOLISM, 2022, 34 (04) :595-+