Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock

被引：49

作者：

Aoyama, Shinya ^{[1
,2
,5
]}

Kim, Hyeon-Ki ^{[1
,2
]}

Hirooka, Rina ^{[1
]}

Tanaka, Mizuho ^{[1
]}

Shimoda, Takeru ^{[1
]}

Chijiki, Hanako ^{[1
]}

Kojima, Shuichi ^{[1
]}

Sasaki, Keisuke ^{[1
]}

Takahashi, Kengo ^{[1
]}

Makino, Saneyuki ^{[1
]}

Takizawa, Miku ^{[1
]}

Takahashi, Masaki ^{[3
]}

Tahara, Yu ^{[1
]}

Shimba, Shigeki ^{[4
]}

Shinohara, Kazuyuki ^{[5
]}

Shibata, Shigenobu ^{[1
]}

机构：

[1] Waseda Univ, Sch Adv Sci & Engn, Lab Physiol & Pharmacol, Tokyo 1628480, Japan

[2] Waseda Univ, Org Univ Res Initiat, Tokyo 1628480, Japan

[3] Tokyo Inst Technol, Inst Liberal Arts, Tokyo 1528550, Japan

[4] Nihon Univ, Sch Pharm, Dept Hlth Sci, Chiba 2748555, Japan

[5] Nagasaki Univ, Grad Sch Biomed Sci, Dept Neurobiol & Behav, Nagasaki 8528523, Japan

来源：

CELL REPORTS | 2021年 / 36卷 / 01期

基金：

日本学术振兴会;

关键词：

BIOELECTRICAL-IMPEDANCE ANALYSIS; CIRCADIAN AUTOPHAGY RHYTHM; BODY-COMPOSITION; AMINO-ACIDS; SARCOPENIA; NUTRITION; LEUCINE; PEOPLE; MASS; RECOMMENDATIONS;

D O I：

10.1016/j.celrep.2021.109336

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The meal distribution of proteins throughout the day is usually skewed. However, its physiological implications and the effects of better protein distribution on muscle volume are largely unknown. Here, using the two-meals-per-day feeding model, we find that protein intake at the early active phase promotes overloading-induced muscle hypertrophy, in amanner dependent on the local muscle clock. Mice fed branched-chain amino acid (BCAA)-supplemented diets at the early active phase demonstrate skeletal muscle hypertrophy. However, distribution-dependent effects are not observed in Clock(Delta 19) or muscle-specific Bmal1 knockout mice. Additionally, we examined the relationship between the distribution of proteins in meals and muscle functions, such as skeletal muscle index and grip strength in humans. Higher muscle functions were observed in subjects who ingested dietary proteins mainly at breakfast than at dinner. These data suggest that protein intake at breakfast may be better for the maintenance of skeletal muscle mass.

引用

页数：18