Leptin receptor action and mechanisms of leptin resistance

被引：207
|
作者：
Münzberg, H
Björnholm, M
Bates, SH
Myers, MG
机构：
[1] Univ Michigan, Sch Med, Div Endocrinol Diabet & Metab, Dept Internal Med, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Div Endocrinol Diabet & Metab, Dept Mol & Physiol, Ann Arbor, MI 48109 USA
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2005年 / 62卷 / 06期
关键词：
leptin; obesity; SOCS3; signaling; arcuate nucleus; hypothalamus;
D O I：
10.1007/s00018-004-4432-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine function. Resistance to the appetite-suppressing effects of leptin is associated with common forms of obesity. Here, we review the mechanisms by which leptin activates intracellular signals and the roles that these signals play in leptin action in vivo. Furthermore, we discuss potential mechanisms of leptin resistance, specifically focusing on data regarding the neuroanatomical locus of leptin resistance and potential mechanisms by which expression of the suppressor of cytokine signaling-3 may impair leptin action.
引用
收藏
页码：642 / 652
页数：11
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