Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder

被引：169

作者：

Miglis, Mitchell G. ^{[1
,2
]}

Adler, Charles H. ^{[3
]}

Antelmi, Elena ^{[4
]}

Arnaldi, Dario ^{[5
,6
]}

Baldelli, Luca ^{[7
]}

Boeve, Bradley F. ^{[8
,9
]}

Cesari, Matteo ^{[10
]}

Dall'Antonia, Irene ^{[11
,12
]}

Diederich, Nico J. ^{[13
]}

Doppler, Kathrin ^{[14
]}

Dusek, Petr ^{[11
,12
]}

Ferri, Raffaele ^{[15
]}

Gagnon, Jean-Francois ^{[16
]}

Gan-Or, Ziv ^{[17
,18
]}

Hermann, Wiebke ^{[19
,20
]}

Hoegl, Birgit ^{[10
]}

Hu, Michele T. ^{[21
]}

Iranzo, Alex ^{[22
]}

Janzen, Annette ^{[23
,24
]}

Kuzkina, Anastasia ^{[14
]}

Lee, Jee-Young ^{[25
]}

Leenders, Klaus L. ^{[26
]}

Lewis, Simon J. G. ^{[27
]}

Liguori, Claudio ^{[28
]}

Liu, Jun ^{[29
]}

Lo, Christine ^{[21
]}

Martens, Kaylena A. Ehgoetz ^{[30
]}

Nepozitek, Jiri ^{[11
,12
]}

Plazzi, Giuseppe ^{[31
,32
]}

Provini, Federica ^{[7
,31
,33
]}

Puligheddu, Monica ^{[34
]}

Rolinski, Michal ^{[35
]}

Rusz, Jan ^{[36
]}

Stefani, Ambra ^{[10
]}

Summers, Rebekah L. S. ^{[37
]}

Yoo, Dallah ^{[38
]}

Zitser, Jennifer ^{[39
,40
]}

Oertel, Wolfgang H. ^{[23
,24
,41
]}

机构：

[1] Stanford Univ, Dept Neurol & Neurol Sci, Palo Alto, CA 94304 USA

[2] Stanford Univ, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA

[3] Mayo Clin, Dept Neurol, Coll Med, Scottsdale, AZ USA

[4] Univ Verona, Dept Neurosci Biomed & Movement Sci, Verona, Italy

[5] Univ Genoa, Clin Neurol, DINOGMI, Genoa, Italy

[6] IRCCS Osped Policlin San Martino, Genoa, Italy

[7] Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy

[8] Mayo Clin, Dept Neurol, Rochester, MN USA

[9] Mayo Clin, Ctr Sleep Med, Rochester, MN USA

[10] Med Univ Innsbruck, Dept Neurol, Innsbruck, Austria

[11] Charles Univ Prague, Fac Med 1, Dept Neurol, Prague, Czech Republic

[12] Charles Univ Prague, Fac Med 1, Ctr Clin Neurosci, Prague, Czech Republic

[13] Ctr Hosp Luxembourg, Dept Neurosci, Luxembourg, Luxembourg

[14] Univ Wurzburg, Dept Neurol, Wurzburg, Germany

[15] Oasi Res Inst IRCCS, Troina, Italy

[16] Hop Sacre Coeur Montreal, Ctr Adv Res Sleep Med, Ctr Integre Univ Sante & Serv Sociaux Nord Ile de, Montreal, PQ, Canada

[17] McGill Univ, Neurol Inst Hosp, Dept Neurol & Neurosurg, Montreal, PQ, Canada

[18] McGill Univ, Dept Human Genet, Montreal, PQ, Canada

[19] Univ Rostock, Dept Neurol, Rostock, Germany

[20] German Ctr Neurodegenerat Dis DZNE, Res Site Rostock, Rostock, Germany

[21] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England

[22] Univ Barcelona, Hosp Clin Barcelona, Sleep Disorders Ctr, Neurol Serv, Barcelona, Spain

[23] Philipps Univ Marburg, Dept Neurol, Marburg, Germany

[24] Philipps Univ Marburg, Sect Clin Neurosci, Marburg, Germany

[25] Seoul Natl Univ, Dept Neurol, Coll Med, Seoul, South Korea

[26] Univ Med Ctr Groningen, Dept Nucl Med & Biomed Imaging, Groningen, Netherlands

[27] Univ Sydney, ForeFront Parkinsons Dis Res Clin, Brain & Mind Ctr, Sydney, NSW, Australia

[28] Univ Roma Tor Vergata, Sleep Med Ctr, Dept Syst Med, Rome, Italy

[29] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Neurol, Sch Med, Shanghai, Peoples R China

[30] Univ Waterloo, Fac Appl Hlth Sci, Dept Kinesiol, Waterloo, ON, Canada

[31] Ist Sci Neurol Bologna, IRCCS, Bologna, Italy

[32] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Modena, Italy

[33] Bellaria Hosp, UOC Clin Neurol Rete Metropolitana NEUROMET, Bologna, Italy

[34] Univ Cagliari, Dept Med Sci & Publ Hlth, Cagliari, Italy

[35] Univ Bristol, Inst Clin Neurosci, Bristol, Avon, England

[36] Czech Tech Univ, Fac Elect Engn, Dept Circuit Theory, Prague, Czech Republic

[37] Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA

[38] Kyung Hee Univ Hosp, Dept Neurol, Seoul, South Korea

[39] Univ Calif San Francisco, Dept Neurol & Neurol Sci, San Francisco, CA 94143 USA

[40] Tel Aviv Univ, Sackler Fac Med, Dept Neurol, Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel

[41] Helmholtz Ctr Hlth & Environm, Inst Neurogenom, Munich, Germany

来源：

LANCET NEUROLOGY | 2021年 / 20卷 / 08期

关键词：

TO-NIGHT VARIABILITY; REM-SLEEP; PARKINSONS-DISEASE; MUSCLE-ACTIVITY; ATONIA INDEX; IDENTIFICATION; DEPOSITS; NEURODEGENERATION; ASSOCIATION; THRESHOLDS;

D O I：

10.1016/S1474-4422(21)00176-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly regarded as being in the early stages of a progressive neurodegenerative disease involving alpha-synuclein pathology, such as Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy. Abnormal alpha-synuclein deposition occurs early in the neurodegenerative process across the central and peripheral nervous systems and might precede the appearance of motor symptoms and cognitive decline by several decades. These findings provide the rationale to develop reliable biomarkers that can better predict conversion to clinically manifest alpha-synucleinopathies. In addition, biomarkers of disease progression will be essential to monitor treatment response once disease-modifying therapies become available, and biomarkers of disease subtype will be essential to enable prediction of which subtype of alpha-synucleinopathy patients with isolated RBD might develop.

引用

页码：671 / 684

页数：14

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