Effects of N6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy

被引：0
作者：
Zhu, Yong-fu [1 ,2 ]
Wang, Shu-Jie [3 ]
Zhou, Jie [2 ]
Sun, Ye-han [1 ]
Chen, You-mou [1 ]
Ma, Jia [1 ]
Huo, Xing-xing [4 ]
Song, Hang [5 ]
机构：
[1] Anhui Univ Chinese Med, Dept Oncol 1, Affiliated Hosp 1, Hefei, Peoples R China
[2] Zhejiang Chinese Med Univ, Dept Acupuncture, Affiliated Hosp 3, Hangzhou, Peoples R China
[3] Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei, Peoples R China
[4] Anhui Univ Chinese Med, Affiliated Hosp 1, Expt Ctr Clin Res, Sci Res Dept, Hefei, Peoples R China
[5] Anhui Univ Chinese Med, Sch Integrated Chinese & Western Med, Dept Biochem & Mol Biol, Hefei, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
基金：
中国国家自然科学基金;
关键词：
RNA modifications; N6-methyladenosine; female malignancies; molecular mechanisms; immunotherapy; INHIBITS CELL-PROLIFERATION; CERVICAL-CANCER; M(6)A MODIFICATION; NONCODING RNAS; METHYLATION; TRANSLATION; METASTASIS; APOPTOSIS; BINDING; ROLES;
D O I：
10.3389/fonc.2022.897895
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
N-6-methyladenosine (m(6)A) is a major internal epigenetic modification in eukaryotic mRNA, which is dynamic and reversible. m(6)A is regulated by methylases ("writers") and demethylases ("erasers") and is recognized and processed by m(6)A-binding proteins ("readers"), which further regulate RNA transport, localization, translation, and degradation. It plays a role in promoting or suppressing tumors and has the potential to become a therapeutic target for malignant tumors. In this review, we focus on the mutual regulation of m(6)A and coding and non-coding RNAs and introduce the molecular mechanism of m(6)A methylation involved in regulation and its role in cancer treatment by taking common female malignant tumors as an example.
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页数：9
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