Cancer stem cells: nature versus nurture

被引：35
作者：
Korkaya, Hasan [1 ]
Wicha, Max S. [1 ]
机构：
[1] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
来源：
NATURE CELL BIOLOGY | 2010年 / 12卷 / 05期
关键词：
IN-VITRO; TUMOR; METASTASIS;
D O I：
10.1038/ncb0510-419
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Although all cells within a colon cancer may harbour adenomatous polyposis coli (APC) or β-catenin mutations, activation of Wnt signalling is limited to a subpopulation of cells that display cancer stem cell properties. This activation requires a co-stimulatory signal mediated by hepatocyte growth factor, which is produced by tumour-associated myofibroblasts.
引用
收藏
页码：419 / 421
页数：3
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