Non-coding RNA in idiopathic interstitial pneumonia and Covid-19 pulmonary fibrosis

被引：5

作者：

Ali, Mohammad Shadab ^{[1
]}

Singh, Jay ^{[2
]}

Alam, Md Tanjim ^{[3
]}

Chopra, Anita ^{[2
]}

Arava, Sudheer ^{[4
]}

Bhalla, Ashu Seith ^{[5
]}

Mittal, Saurabh ^{[1
]}

Mohan, Anant ^{[1
]}

Mitra, Dipendra K. ^{[6
]}

Hadda, Vijay ^{[1
]}

机构：

[1] All India Inst Med Sci, Dept Pulm Crit Care & Sleep Med, New Delhi, India

[2] All India Inst Med Sci, Dr BRA IRCH, Lab Oncol Unit, New Delhi, India

[3] CSIR Indian Inst Chem Biol, Kolkata, India

[4] All India Inst Med Sci, Dept Pathol, New Delhi, India

[5] All India Inst Med Sci, Dept Radiodiag, New Delhi, India

[6] All India Inst Med Sci, Dept Transplant Immunol & Immunogenet, New Delhi, India

来源：

MOLECULAR BIOLOGY REPORTS | 2022年 / 49卷 / 12期

关键词：

Pulmonary fibrosis; IIP; Covid-19; lncRNA; miRNA; circRNA; RESPIRATORY-DISTRESS-SYNDROME; ACUTE LUNG INJURY; CIRCULAR RNAS; MECHANISMS; EXPRESSION; FIBROBLASTS; ACTIVATION;

D O I：

10.1007/s11033-022-07820-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pulmonary fibrosis is the key feature of majority of idiopathic interstitial pneumonias (IIPs) as well as many patients with post-COVID-19. The pathogenesis of pulmonary fibrosis is a complex molecular process that involves myriad of cells, proteins, genes, and regulatory elements. The non-coding RNA mainly miRNA, circRNA, and lncRNA are among the key regulators of many protein coding genes and pathways that are involved in pulmonary fibrosis. Identification and molecular mechanisms, by which these non-coding RNA molecules work, are crucial to understand the molecular basis of the disease. Additionally, elucidation of molecular mechanism could also help in deciphering a potential diagnostic/prognostic marker as well as therapeutic targets for IIPs and post-COVID-19 pulmonary fibrosis. In this review, we have provided the latest findings and discussed the role of these regulatory elements in the pathogenesis of pulmonary fibrosis associated with Idiopathic Interstitial Pneumonia and Covid-19.

引用

页码：11535 / 11546

页数：12

共 90 条

[1] AGO CLIP-based imputation of potent siRNA sequences targeting SARS-CoV-2 with antifibrotic miRNA-like activity [J].

Ahn, Seung Hyun ;

Gu, Dowoon ;

Koh, Yongjun ;

Lee, Hye-Sook ;

Chi, Sung Wook .

SCIENTIFIC REPORTS, 2021, 11 (01)

[2] Post-COVID-19 Pulmonary Fibrosis: Novel Sequelae of the Current Pandemic [J].

Ambardar, Shiva Rattan ;

Hightower, Stephanie L. ;

Huprikar, Nikhil A. ;

Chung, Kevin K. ;

Singhal, Anju ;

Collen, Jacob F. .

JOURNAL OF CLINICAL MEDICINE, 2021, 10 (11)

[3]

[Anonymous], MIR 21 PROMOTES PULM

[4] Pathogenetic pathways and novel pharmaco therapeutic targets in idiopathic pulmonary fibrosis [J].

Antomou, Katerma M. ;

Pataka, Athanasia ;

Bouros, Demosthenes ;

Slafakas, Nikolaos M. .

PULMONARY PHARMACOLOGY & THERAPEUTICS, 2007, 20 (05) :453-461

[5]

Balmeh Negar, 2020, Inform Med Unlocked, V20, P100407, DOI 10.1016/j.imu.2020.100407

[6] NON-CODING RNAs IN DEVELOPMENT AND DISEASE: BACKGROUND, MECHANISMS, AND THERAPEUTIC APPROACHES [J].

Beermann, Julia ;

Piccoli, Maria-Teresa ;

Viereck, Janika ;

Thum, Thomas .

PHYSIOLOGICAL REVIEWS, 2016, 96 (04) :1297-1325

[7] Mechanical Ventilation-associated Lung Fibrosis in Acute Respiratory Distress Syndrome A Significant Contributor to Poor Outcome [J].

Cabrera-Benitez, Nuria E. ;

Laffey, John G. ;

Parotto, Matteo ;

Spieth, Peter M. ;

Villar, Jesus ;

Zhang, Haibo ;

Slutsky, Arthur S. .

ANESTHESIOLOGY, 2014, 121 (01) :189-198

[8] circHIPK2-mediated σ-1R promotes endoplasmic reticulum stress in human pulmonary fibroblasts exposed to silica [J].

Cao, Zhouli ;

Xiao, Qingling ;

Dai, Xiaoniu ;

Zhou, Zewei ;

Jiang, Rong ;

Cheng, Yusi ;

Yang, Xiyue ;

Guo, Huifang ;

Wang, Jing ;

Xi, Zhaoqing ;

Yao, Honghong ;

Chao, Jie .

CELL DEATH & DISEASE, 2017, 8

[9] miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1 [J].

Cardenas, Christian Lacks Lino ;

Henaoui, Imene Sarah ;

Courcot, Elisabeth ;

Roderburg, Christoph ;

Cauffiez, Christelle ;

Aubert, Sebastien ;

Copin, Marie-Christine ;

Wallaert, Benoit ;

Glowacki, Francois ;

Dewaeles, Edmone ;

Milosevic, Jadranka ;

Maurizio, Julien ;

Tedrow, John ;

Marcet, Brice ;

Lo-Guidice, Jean-Marc ;

Kaminski, Naftali ;

Barbry, Pascal ;

Luedde, Tom ;

Perrais, Michael ;

Mari, Bernard ;

Pottier, Nicolas .

PLOS GENETICS, 2013, 9 (02)

[10] CircRNA-012091/PPP1R13B-mediated Lung Fibrotic Response in Silicosis via Endoplasmic Reticulum Stress and Autophagy [J].

Chang, Yusi ;

Luo, Wei ;

Li, Zhuang ;

Cao, Mumin ;

Zhu, Zixin ;

Han, Chen ;

Dai, Xiaoniu ;

Zhang, Wei ;

Wang, Jing ;

Yao, Honghong ;

Chao, Jie .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2019, 61 (03) :380-391

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