THERMAL AND PH SENSITIVE NANO/MICROGELS OF N-ISOPROPYLACRYLAMIDE AND CARBOXYALKYL METHACRYLATES

被引：0

作者：

Castro-Vidal, D. A. ^{[1
]}

Obeso-Vera, C. ^{[1
]}

Suarez-Meraz, K. A. ^{[1
]}

Lara-Molinero, B. M. ^{[1
]}

Serrano-Medina, A. ^{[1
]}

Cornejo-Bravo, J. M. ^{[1
]}

机构：

[1] Univ Autonoma Baja California, Fac Ciencias Quim & Ingn, Calzada Univ 14418 Parque Ind Int Tijua, Tijuana Bc 22390, Mexico

来源：

DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES | 2016年 / 11卷 / 01期

关键词：

Methacrylates; Dispersion polymerization; Nanogels; N-isopropylacrylamide; Dual sensitive polymers; HYDROPHOBIC SPACERS; SWELLING PROPERTIES; MICROGEL PARTICLES; DRUG-DELIVERY; TEMPERATURE; COPOLYMER; HYDROGELS; POLYMERS; BEHAVIOR; POLY(N-ISOPROPYLACRYLAMIDE);

D O I：

暂无

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

We synthesized thermal and pH sensitive nanogels and microgels by a dispersion polymerization method, consisted of N-isopropylacrylamide (NIPAAm) and two different carboxyalkyl methacrylates (CAM): 5-methacryloyloxypantenoate potassium salt (M4K), or 11-methacryloyloxyundecanoate potassium salt (M10K). Monodisperse particles were produced with proportions of 5, 10 and 15 mol% of acid comonomers. For the NIPAAm/M4K copolymers the transition temperature is tuned with the content of the acid monomer; for instance those materials have potential for biomedical applications, such as temperature and/or pH responsive drug delivery. On the other hand, the copolymers with M10K present a size one order of magnitude smaller since the amphiphilic acid monomer acts as a surfactant, however due to the predominantly hydrophobic characteristics of the acid monomer the transition temperature cannot be increased above the temperature of homopolymeric NIPAAm microgels.

引用

页码：123 / 132

页数：10

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