Fibrin in Reproductive Tissue Engineering: A Review on Its Application as a Biomaterial for Fertility Preservation

被引:55
作者
Chiti, M. C. [1 ]
Dolmans, M. M. [1 ,2 ]
Donnez, J. [3 ]
Amorim, C. A. [1 ]
机构
[1] Catholic Univ Louvain, Inst Rech Expt & Clin, Pole Rech Gynecol, Ave Mounier 52,Bte B1-52-02, B-1200 Brussels, Belgium
[2] Clin Univ St Luc, Dept Gynecol, B-1200 Brussels, Belgium
[3] Soc Res Infertil, Brussels, Belgium
关键词
Tissue engineering; Ovarian tissue transplantation; In vitro artificial ovary; Transplantable artificial ovary; PRIMARY OVARIAN-FOLLICLES; ISOLATED MURINE FOLLICLES; PRE-ANTRAL FOLLICLES; IN-VITRO; ARTIFICIAL OVARY; PREANTRAL FOLLICLES; CLINICAL-PRACTICE; CANCER-PATIENTS; STROMAL CELLS; GROWTH-FACTOR;
D O I
10.1007/s10439-017-1817-5
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
In recent years, reproductive medicine has made good use of tissue engineering and regenerative medicine techniques to develop alternatives to restore fertility in cancer patients. For young female cancer patients who cannot undergo any of the currently applied strategies due to the possible presence of malignant cells in their ovaries, the challenge is creating an in vitro or in vivo artificial ovary using carefully selected biomaterials. Thanks to its numerous qualities, fibrin has been widely used as a scaffold material for fertility preservation applications. The goal of this review is to examine and discuss the applications and advantages of this biopolymer for fertility restoration in cancer patients, and consider the main results achieved so far.
引用
收藏
页码:1650 / 1663
页数:14
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