Could A Deletion in Neuraminidase Stalk Strengthen Human Tropism of the Novel Avian Influenza Virus H7N9 in China, 2013?

被引：6

作者：

Chen, Liang ^{[1
,2
]}

Zhu, Feng ^{[3
]}

Xiong, Chenglong ^{[1
,2
]}

Zhang, Zhijie ^{[2
,4
]}

Jiang, Lufang ^{[1
,2
]}

Chen, Yue ^{[5
]}

Zhao, Genming ^{[2
,4
]}

Jiang, Qingwu ^{[2
]}

机构：

[1] Fudan Univ, Sch Publ Hlth, Dept Sanit Microbiol, Shanghai 200032, Peoples R China

[2] Fudan Univ, Key Lab Publ Hlth Safety, Minist Educ, Shanghai 200032, Peoples R China

[3] Second Mil Med Univ, Changhai Hosp, Intens Care Unit, Burn & Trauma Ctr, Shanghai 200433, Peoples R China

[4] Fudan Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Shanghai 200032, Peoples R China

[5] Univ Ottawa, Fac Med, Dept Epidemiol & Community Med, Ottawa, ON K1H 8M5, Canada

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2015年 / 12卷 / 01期

基金：

中国国家自然科学基金;

关键词：

deletion; neuraminidase; H7N9; China; H5N1; HEMAGGLUTININ;

D O I：

10.3390/ijerph120101020

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Objective. A novel avian influenza A virus (AIV) H7N9 subtype which emerged in China in 2013 caused worldwide concern. Deletion of amino-acids 69 to 73 in the neuraminidase stalk was its most notable characteristic. This study is aimed to discuss the tropism and virulence effects of this deletion. Methods: Neuraminidase gene sequences of N9 subtype were collected from NCBI and GISAID. MEGA6.0, Stata12.0, and UCSF Chimera were employed for sequence aligning, significance testing, and protein tertiary structure homology modeling. Results: A total of 736 sequences were obtained; there were 81 human isolates of the novel AIV H7N9, of which 79 had the deletion. Among all the 654 avian origin sequences, only 43 had the deletion (p<0.001). Tertiary structure displayed that the deletion obviously changed the spatial direction of neuraminidase. Conclusions: The deletion in neuraminidase stalk could have strengthened human tropism of the novel AIV H7N9, as well as its virulence.

引用

页码：1020 / 1028

页数：9

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