A Multifunctional Smart Soft Contact Lens Device Enabled by Nanopore Thin Film for Glaucoma Diagnostics and In Situ Drug Delivery

被引：34
|
作者：
Song, Chao [1 ]
Ben-Shlomo, Gil [2 ]
Que, Long [1 ]
机构：
[1] Iowa State Univ, Dept Elect & Comp Engn, Ames, IA 50011 USA
[2] Iowa State Univ, Dept Vet Clin Sci, Ames, IA 50011 USA
来源：
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS | 2019年 / 28卷 / 05期
关键词：
Contact lens device; nanopore thin film; intraocular pressure; drug release; biomarker for ocular diseases; INTRAOCULAR-PRESSURE; TEAR FILM; BIOMARKERS; NUMBER; SENSOR;
D O I：
10.1109/JMEMS.2019.2927232
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
In this paper, we report a new power-free multifunctional soft contact lens device that can measure intraocular pressure (IOP), achieve extended drug delivery in situ, and detect glaucoma biomarkers, all within the same device. Experiments demonstrate that the contact lens sensor can detect Interleukin 12p70, one possible biomarker for glaucoma, in a concentration as low as 2 pg/ml in artificial tears. The sustained drug release of the contact lens device can last up to 30 days. In ex vivo tests using cadaver pig eyes, the sensor detected IOP in a range of 10-50 mmHg with excellent repeatability.
引用
收藏
页码：810 / 816
页数：7
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