Whole-Genome Sequencing to Determine Origin of Multinational Outbreak of Sarocladium kiliense Bloodstream Infections

被引：38

作者：

Etienne, Kizee A. ^{[1
,2
]}

Roe, Chandler C. ^{[3
]}

Smith, Rachel M. ^{[1
]}

Vallabhaneni, Snigdha ^{[1
]}

Duarte, Carolina ^{[4
]}

Escandon, Patricia ^{[4
]}

Castaneda, Elizabeth ^{[4
]}

Gomez, Beatriz L. ^{[5
,6
]}

de Bedout, Catalina ^{[6
]}

Lopez, Luisa F. ^{[6
]}

Salas, Valentina ^{[7
]}

Maria Hederra, Luz ^{[7
]}

Fernandez, Jorge ^{[7
]}

Pidal, Paola ^{[7
]}

Carlos Hormazabel, Juan ^{[7
]}

Otaiza-O'Ryan, Fernando ^{[8
]}

Vannberg, Fredrik O. ^{[2
]}

Gillece, John ^{[3
]}

Lemmer, Darrin ^{[3
]}

Driebe, Elizabeth M. ^{[3
]}

Engelthaler, David M. ^{[3
]}

Litvintseva, Anastasia P. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop G11, Atlanta, GA 30329 USA

[2] Georgia Inst Technol, Atlanta, GA 30332 USA

[3] Translat Genom Res Inst, Flagstaff, AZ USA

[4] Inst Nacl Salud, Bogota, Colombia

[5] Univ Rosario, Bogota, Colombia

[6] Corp Invest Biol, Medellin, Colombia

[7] Inst Salud Publ Chile, Santiago, Chile

[8] Minist Hlth Santiago, Santiago, Chile

来源：

EMERGING INFECTIOUS DISEASES | 2016年 / 22卷 / 03期

关键词：

ENDOPHTHALMITIS;

D O I：

10.3201/eid2203.151193

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We used whole-genome sequence typing (WGST) to investigate an outbreak of Sarocladium kiliense bloodstream infections (BSI) associated with receipt of contaminated antinausea medication among oncology patients in Colombia and Chile during 2013-2014. Twenty-five outbreak isolates (18 from patients and 7 from medication vials) and 11 control isolates unrelated to this outbreak were subjected to WGST to elucidate a source of infection. All outbreak isolates were nearly indistinguishable (<= 5 single-nucleotide polymorphisms), and >21,000 single-nucleotide polymorphisms were identified from unrelated control isolates, suggesting a point source for this outbreak. S. kiliense has been previously implicated in healthcare-related infections; however, the lack of available typing methods has precluded the ability to substantiate point sources. WGST for outbreak investigation caused by eukaryotic pathogens without reference genomes or existing genotyping methods enables accurate source identification to guide implementation of appropriate control and prevention measures.

引用

页码：476 / 481

页数：6

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