In-hospital management and outcomes in patients with peripartum cardiomyopathy: a descriptive study using a national inpatient database in Japan

被引:11
作者
Isogai, Toshiaki [1 ,2 ]
Matsui, Hiroki [1 ]
Tanaka, Hiroyuki [2 ]
Fushimi, Kiyohide [3 ]
Yasunaga, Hideo [1 ]
机构
[1] Univ Tokyo, Sch Publ Hlth, Dept Clin Epidemiol & Hlth Econ, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan
[2] Tokyo Metropolitan Tama Med Ctr, Dept Cardiol, Tokyo, Japan
[3] Tokyo Med & Dent Univ, Grad Sch Med, Dept Hlth Policy & Informat, Tokyo, Japan
关键词
Peripartum cardiomyopathy; Mortality; Complication; Implantable cardioverter defibrillator; Prolactin blockade; IDIOPATHIC DILATED CARDIOMYOPATHY; HEART-FAILURE ASSOCIATION; LEFT-VENTRICULAR FUNCTION; ENDOMYOCARDIAL BIOPSY; EUROPEAN-SOCIETY; UNITED-STATES; EPIDEMIOLOGY; PREDICTORS; CARDIOLOGY; MORTALITY;
D O I
10.1007/s00380-017-0958-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Peripartum cardiomyopathy (PPCM) is a rare but life-threatening cardiac disorder characterized by maternal systolic heart failure. Although PPCM is a major cause of maternal mortality, little is known about the acute-phase management of PPCM in real-world clinical settings. We retrospectively identified patients hospitalized with PPCM from 2007 to 2014 using the Diagnosis Procedure Combination database in Japan. We investigated patient characteristics, in-hospital examinations and treatment, and in-hospital outcomes. The study patients were 283 patients hospitalized with PPCM at 177 hospitals. The mean age was 32.7 +/- 5.5 years. Of the eligible patients, 134 (47.3%) patients had a hypertensive disorder, including 48 (17.0%) patients with pre-eclampsia, and 111 (39.2%) patients were admitted to the intensive care unit or emergency center. Coronary angiography, cardiac magnetic resonance imaging, and endomyocardial biopsy were performed during hospitalization in 69 (24.4%), 42 (14.8%), and 43 (15.2%) patients, respectively. Invasive pulmonary artery pressure monitoring was used in 14 (4.9%) patients. Mechanical circulatory support was used in 13 (4.6%) patients (intra-aortic balloon pumping, n = 12; extracorporeal membrane oxygenation, n = 5; ventricular assist device, n = 0). Catecholamine therapy and phosphodiesterase-III inhibitor therapy were used in 79 (27.9%) and 13 (4.6%) patients, respectively. Prolactin blockade therapy was used in 78 (27.6%) patients. During hospitalization, four (1.4%) patients died and nine (3.2%) patients developed ventricular tachycardia or fibrillation. Two (0.7%) patients received an implantable cardioverter defibrillator, but no patient received other permanent cardiac devices. This retrospective cohort study suggests that attending physicians should be ready to provide intensive care for patients with PPCM during the acute phase.
引用
收藏
页码:944 / 951
页数:8
相关论文
共 39 条
[1]   Characteristics and In-Hospital Outcomes of Peripartum Cardiomyopathy Diagnosed During Delivery in the United States From the Nationwide Inpatient Sample (NIS) Database [J].
Afana, Majed ;
Brinjikji, Waleed ;
Kao, David ;
Jackson, Elizabeth ;
Maddox, Thomas M. ;
Childers, David ;
Eagle, Kim A. ;
Davis, Melinda B. .
JOURNAL OF CARDIAC FAILURE, 2016, 22 (07) :512-519
[2]   Current management of patients with severe acute peripartum cardiomyopathy: practical guidance from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy [J].
Bauersachs, Johann ;
Arrigo, Mattia ;
Hilfiker-Kleiner, Denise ;
Veltmann, Christian ;
Coats, Andrew J. S. ;
Crespo-Leiro, Maria G. ;
De Boer, Rudolf A. ;
van der Meer, Peter ;
Maack, Christoph ;
Mouquet, Frederic ;
Petrie, Mark C. ;
Piepoli, Massimo F. ;
Regitz-Zagrosek, Vera ;
Schaufelberger, Maria ;
Seferovic, Petar ;
Tavazzi, Luigi ;
Ruschitzka, Frank ;
Mebazaa, Alexandre ;
Sliwa, Karen .
EUROPEAN JOURNAL OF HEART FAILURE, 2016, 18 (09) :1096-1105
[3]   Severe adverse effects of bromocriptine in lactation inhibition: a pharmacovigilance survey [J].
Bernard, N. ;
Jantzem, H. ;
Becker, M. ;
Pecriaux, C. ;
Benard-Laribiere, A. ;
Montastruc, J. L. ;
Descotes, J. ;
Vial, T. .
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2015, 122 (09) :1244-1251
[4]   Predictors of outcome in 176 South African patients with peripartum cardiomyopathy [J].
Blauwet, Lori A. ;
Libhaber, Elena ;
Forster, Olaf ;
Tibazarwa, Kemi ;
Mebazaa, Alex ;
Hilfiker-Kleiner, Denise ;
Sliwa, Karen .
HEART, 2013, 99 (05) :308-313
[5]   The Medical Treatment of New-Onset Peripartum Cardiomyopathy: A Systematic Review of Prospective Studies [J].
Desplantie, Olivier ;
Tremblay-Gravel, Maxime ;
Avram, Robert ;
Marquis-Gravel, Guillaume ;
Ducharme, Anique ;
Jolicoeur, E. Marc .
CANADIAN JOURNAL OF CARDIOLOGY, 2015, 31 (12) :1421-1426
[6]   Risk for ventricular fibrillation in peripartum cardiomyopathy with severely reduced left ventricular function-value of the wearable cardioverter/defibrillator [J].
Duncker, David ;
Haghikia, Arash ;
Koenig, Thorben ;
Hohmann, Stephan ;
Gutleben, Klaus-Juergen ;
Westenfeld, Ralf ;
Oswald, Hanno ;
Klein, Helmut ;
Bauersachs, Johann ;
Hilfiker-Kleiner, Denise ;
Veltmann, Christian .
EUROPEAN JOURNAL OF HEART FAILURE, 2014, 16 (12) :1331-1336
[7]   Epidemiology of Peripartum Cardiomyopathy Incidence, Predictors, and Outcomes [J].
Gunderson, Erica P. ;
Croen, Lisa A. ;
Chiang, Vicky ;
Yoshida, Cathleen K. ;
Walton, David ;
Go, Alan S. .
OBSTETRICS AND GYNECOLOGY, 2011, 118 (03) :583-591
[8]   Phenotyping and outcome on contemporary management in a German cohort of patients with peripartum cardiomyopathy [J].
Haghikia, A. ;
Podewski, E. ;
Libhaber, E. ;
Labidi, S. ;
Fischer, D. ;
Roentgen, P. ;
Tsikas, D. ;
Jordan, J. ;
Lichtinghagen, R. ;
von Kaisenberg, C. S. ;
Struman, I. ;
Bovy, N. ;
Sliwa, K. ;
Bauersachs, J. ;
Hilfiker-Kleiner, Denise .
BASIC RESEARCH IN CARDIOLOGY, 2013, 108 (04)
[9]   Current status of pregnancy-related maternal mortality in Japan: a report from the Maternal Death Exploratory Committee in Japan [J].
Hasegawa, Junichi ;
Sekizawa, Akihiko ;
Tanaka, Hiroaki ;
Katsuragi, Shinji ;
Osato, Kazuhiro ;
Murakoshi, Takeshi ;
Nakata, Masahiko ;
Nakamura, Masamitsu ;
Yoshimatsu, Jun ;
Sadahiro, Tomohito ;
Kanayama, Naohiro ;
Ishiwata, Isamu ;
Kinoshita, Katsuyuki ;
Ikeda, Tomoaki .
BMJ OPEN, 2016, 6 (03)
[10]   A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy [J].
Hilfiker-Kleiner, Denise ;
Kaminski, Karol ;
Podewski, Edith ;
Bonda, Tomasz ;
Schaefer, Arnd ;
Sliwa, Karen ;
Forster, Olaf ;
Quint, Anja ;
Landmesser, Ulf ;
Doerries, Carola ;
Luchtefeld, Maren ;
Poli, Valeria ;
Schneider, Michael D. ;
Balligand, Jean-Luc ;
Desjardins, Fanny ;
Ansari, Aftab ;
Struman, Ingrid ;
Nguyen, Ngoc Q. N. ;
Zschemisch, Nils H. ;
Klein, Gunnar ;
Heusch, Gerd ;
Schulz, Rainer ;
Hilfiker, Andres ;
Drexler, Helmut .
CELL, 2007, 128 (03) :589-600