Synthesis of some 5-amino-2-methyl-4-nitro-1-phenacylimidazoles

被引：0
作者：
Sobiak, S [1 ]
机构：
[1] K Marcinkowski Univ Med Sci, Fac Pharm, Dept Chem Technol Drugs, PL-60780 Poznan, Poland
来源：
POLISH JOURNAL OF CHEMISTRY | 1998年 / 72卷 / 01期
关键词：
nitroimidazoles; bromonitroimidazoles; aminonitroimidazoles; anticancer activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reaction of 4(5)-bromo-2-methyl-5(4)-nitroimidazole with phenacyl bromide derivatives gave two isomers: 4-bromo-5-nitroimidazoles (4a-e) and 5-bromo-4-nitroimidazoles (5a-e). Compounds 5a-e were treated with cyclic secondary amines to afford expected 5-amino-4-nitroimidazole derivatives 6a-c-10a-b.
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页码：78 / 83
页数：6
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