Synthesis of some 5-amino-2-methyl-4-nitro-1-phenacylimidazoles

被引：0

作者：

Sobiak, S ^{[1
]}

机构：

[1] K Marcinkowski Univ Med Sci, Fac Pharm, Dept Chem Technol Drugs, PL-60780 Poznan, Poland

来源：

POLISH JOURNAL OF CHEMISTRY | 1998年 / 72卷 / 01期

关键词：

nitroimidazoles; bromonitroimidazoles; aminonitroimidazoles; anticancer activity;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reaction of 4(5)-bromo-2-methyl-5(4)-nitroimidazole with phenacyl bromide derivatives gave two isomers: 4-bromo-5-nitroimidazoles (4a-e) and 5-bromo-4-nitroimidazoles (5a-e). Compounds 5a-e were treated with cyclic secondary amines to afford expected 5-amino-4-nitroimidazole derivatives 6a-c-10a-b.

引用

页码：78 / 83

页数：6

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