Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease

被引:245
|
作者
Barreto, Daniela V. [2 ]
Barreto, Fellype C. [2 ]
Liabeuf, Sophie [2 ]
Temmar, Mohammed
Lemke, Horst-Dieter [3 ]
Tribouilloy, Christophe [2 ,4 ]
Choukroun, Gabriel [2 ,5 ]
Vanholder, Raymond [6 ]
Massy, Ziad A. [1 ,2 ,5 ]
机构
[1] Amiens Univ Hosp, Div Clin Pharmacol, ERI 12, INSERM,EA 4292, F-80054 Amiens, France
[2] Jules Verne Univ Picardy, Amiens, France
[3] EXcorLab GmbH, Obernburg, Germany
[4] Amiens Univ Hosp, Div Cardiol, F-80054 Amiens, France
[5] Amiens Univ Hosp, Div Nephrol, F-80054 Amiens, France
[6] Ghent Univ Hosp, Dept Internal Med, Nephrol Sect, B-9000 Ghent, Belgium
关键词
cardiovascular disease; chronic kidney disease; inflammation; mortality; vascular calcification; C-REACTIVE PROTEIN; CHRONIC-RENAL-FAILURE; CARDIOVASCULAR MORTALITY; ANGIOTENSIN-II; MYOCARDIAL-INFARCTION; INFLAMMATORY MARKERS; CARDIAC-DISEASE; TNF-ALPHA; ALL-CAUSE; RISK;
D O I
10.1038/ki.2009.503
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Chronic inflammation associated with chronic kidney disease predicts all-cause and cardiovascular mortality in hemodialysis patients. Here we sought to evaluate the association between plasma levels of the inflammatory mediator interleukin-6 (IL-6) and mortality and aortic calcification/stiffness in 125 patients at different stages (2-5D) of chronic kidney disease. Using multivariate linear regression, we found that plasma IL-6 was independently associated with C-reactive protein, albumin and the stage of chronic kidney disease, but not the aortic calcification score or pulse wave velocity. During follow-up studies (median of 829 days), 38 patients died, 22 from cardiovascular events. Plasma IL-6 significantly predicted overall and cardiovascular mortality; this association persisted after multiple adjustments or restricting the analysis to pre-dialysis patients. Moreover, IL-6 was a significantly better predictor of mortality than C-reactive protein, albumin or tumor necrosis factor-a. Hence, plasma IL-6 independently predicted overall and cardiovascular mortality in patients at different stages of chronic kidney disease; however, whether lowering plasma IL-6 will affect the outcome of chronic kidney disease will require more direct evaluation. Kidney International (2010) 77, 550-556; doi: 10.1038/ki.2009.503; published online 16 December 2009
引用
收藏
页码:550 / 556
页数:7
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