Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease

被引:245
|
作者
Barreto, Daniela V. [2 ]
Barreto, Fellype C. [2 ]
Liabeuf, Sophie [2 ]
Temmar, Mohammed
Lemke, Horst-Dieter [3 ]
Tribouilloy, Christophe [2 ,4 ]
Choukroun, Gabriel [2 ,5 ]
Vanholder, Raymond [6 ]
Massy, Ziad A. [1 ,2 ,5 ]
机构
[1] Amiens Univ Hosp, Div Clin Pharmacol, ERI 12, INSERM,EA 4292, F-80054 Amiens, France
[2] Jules Verne Univ Picardy, Amiens, France
[3] EXcorLab GmbH, Obernburg, Germany
[4] Amiens Univ Hosp, Div Cardiol, F-80054 Amiens, France
[5] Amiens Univ Hosp, Div Nephrol, F-80054 Amiens, France
[6] Ghent Univ Hosp, Dept Internal Med, Nephrol Sect, B-9000 Ghent, Belgium
关键词
cardiovascular disease; chronic kidney disease; inflammation; mortality; vascular calcification; C-REACTIVE PROTEIN; CHRONIC-RENAL-FAILURE; CARDIOVASCULAR MORTALITY; ANGIOTENSIN-II; MYOCARDIAL-INFARCTION; INFLAMMATORY MARKERS; CARDIAC-DISEASE; TNF-ALPHA; ALL-CAUSE; RISK;
D O I
10.1038/ki.2009.503
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Chronic inflammation associated with chronic kidney disease predicts all-cause and cardiovascular mortality in hemodialysis patients. Here we sought to evaluate the association between plasma levels of the inflammatory mediator interleukin-6 (IL-6) and mortality and aortic calcification/stiffness in 125 patients at different stages (2-5D) of chronic kidney disease. Using multivariate linear regression, we found that plasma IL-6 was independently associated with C-reactive protein, albumin and the stage of chronic kidney disease, but not the aortic calcification score or pulse wave velocity. During follow-up studies (median of 829 days), 38 patients died, 22 from cardiovascular events. Plasma IL-6 significantly predicted overall and cardiovascular mortality; this association persisted after multiple adjustments or restricting the analysis to pre-dialysis patients. Moreover, IL-6 was a significantly better predictor of mortality than C-reactive protein, albumin or tumor necrosis factor-a. Hence, plasma IL-6 independently predicted overall and cardiovascular mortality in patients at different stages of chronic kidney disease; however, whether lowering plasma IL-6 will affect the outcome of chronic kidney disease will require more direct evaluation. Kidney International (2010) 77, 550-556; doi: 10.1038/ki.2009.503; published online 16 December 2009
引用
收藏
页码:550 / 556
页数:7
相关论文
共 50 条
  • [1] Homoarginine and Mortality in Pre-Dialysis Chronic Kidney Disease (CKD) Patients
    Ravani, Pietro
    Maas, Renke
    Malberti, Fabio
    Pecchini, Paola
    Mieth, Maren
    Quinn, Robert
    Tripepi, Giovanni
    Mallamaci, Francesca
    Zoccali, Carmine
    PLOS ONE, 2013, 8 (09):
  • [2] Pre-dialysis education for patients with chronic kidney disease
    Thomas, Merlin C.
    NEPHROLOGY, 2007, 12 : S46 - S48
  • [3] Plasma Xanthine Oxidoreductase Activity Associated with Glycemic Control in Patients with Pre-Dialysis Chronic Kidney Disease
    Nakatani, Shinya
    Ishimura, Eiji
    Murase, Takayo
    Nakamura, Takashi
    Nakatani, Ayumi
    Toi, Norikazu
    Nishide, Kozo
    Uedono, Hideki
    Tsuda, Akihiro
    Kurajoh, Masafumi
    Yamada, Shinsuke
    Mori, Katsuhito
    Inaba, Masaaki
    Emoto, Masanori
    KIDNEY & BLOOD PRESSURE RESEARCH, 2021, 46 (04): : 475 - 483
  • [4] Pharmacotherapy of hypertension in patients with pre-dialysis chronic kidney disease
    Loutradis, Charalampos
    Sarafidis, Pantelis
    EXPERT OPINION ON PHARMACOTHERAPY, 2020, 21 (10) : 1201 - 1217
  • [5] The periodontal status of pre-dialysis chronic kidney disease and maintenance dialysis patients
    Borawski, Jacek
    Wilczynska-Borawska, Magdalena
    Stokowska, Wanda
    Mysliwiec, Michal
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2007, 22 (02) : 457 - 464
  • [6] ASSOCIATION OF PRE-DIALYSIS MEDICATION ADHERENCE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE WITH MORTALITY AFTER TRANSITION TO DIALYSIS
    Molnar, Miklos Z.
    Gosmanova, Elvira O.
    Sumida, Keiichi
    Potukuchi, Praveen K.
    Lu, Jun L.
    Jing, Jennie
    Ravel, Vanessa A.
    Soohoo, Melissa
    Rhee, Connie M.
    Streja, Elani
    Kalantar-Zadeh, Kamyar
    Kovesdy, Csaba P.
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2016, 31 : 21 - 21
  • [7] Plasma interleukin-6 predicts cardiovascular mortality in hemodialysis patients
    Rao, M
    Guo, DQ
    Perianayagam, MC
    Tighiouart, H
    Jaber, BL
    Pereira, BJG
    Balakrishnan, VS
    AMERICAN JOURNAL OF KIDNEY DISEASES, 2005, 45 (02) : 324 - 333
  • [8] Plasma neutrophil gelatinase-associated lipocalin is associated with iron status in anemic patients with pre-dialysis chronic kidney disease
    Il Young Kim
    Joo Hui Kim
    Dong Won Lee
    Soo Bong Lee
    Harin Rhee
    Sang Heon Song
    Eun Young Seong
    Ihm Soo Kwak
    Clinical and Experimental Nephrology, 2018, 22 : 28 - 34
  • [9] Epidemiology and determinants of pruritus in pre-dialysis chronic kidney disease patients
    Solak, Berna
    Acikgoz, Seyyid Bilal
    Sipahi, Savas
    Erdem, Teoman
    INTERNATIONAL UROLOGY AND NEPHROLOGY, 2016, 48 (04) : 585 - 591
  • [10] Plasma neutrophil gelatinase-associated lipocalin is associated with iron status in anemic patients with pre-dialysis chronic kidney disease
    Kim, Il Young
    Kim, Joo Hui
    Lee, Dong Won
    Lee, Soo Bong
    Rhee, Harin
    Song, Sang Heon
    Seong, Eun Young
    Kwak, Ihm Soo
    CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2018, 22 (01) : 28 - 34