The Protective Effect of Semax in a Model of Stress-Induced Impairment of Memory and Behavior in White Rats

被引：6
作者：
Glazova, N. Yu. [1 ]
Sebentsova, E. A. [1 ]
Manchenko, D. M. [2 ]
Andreeva, L. A. [1 ]
Dergunova, L. V. [1 ]
Levitskaya, N. G. [1 ,2 ]
Limborska, S. A. [1 ]
Myasoedov, N. F. [1 ]
机构：
[1] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia
[2] Moscow MV Lomonosov State Univ, Fac Biol, Moscow 119992, Russia
来源：
BIOLOGY BULLETIN | 2018年 / 45卷 / 04期
基金：
俄罗斯科学基金会;
关键词：
ACUTE RESTRAINT STRESS; ACTH(4-10) ANALOG; SPATIAL MEMORY; FEMALE RATS; PRETREATMENT; RECOGNITION; HIPPOCAMPUS; EXPERIENCE; ANXIETY; SYSTEMS;
D O I：
10.1134/S1062359018040040
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The effect of acute restrained stress on cognitive functions and anxiety-like behavior in white rats has been studied; furthermore, the influence of the fragment ACTH(4-10) analog Semax on the stress effects was evaluated. It was shown that stress exposure leads to impaired retention of previously acquired food-motivated maze task as well as reduced anxiety-like behavior in the elevated plus maze in rats. Preliminary intraperitonial administration of Semax (0.1 mg/kg) attenuates cognitive impairment caused by acute restrained stress, but it does not affect stress-induced changes in anxiety.
引用
收藏
页码：394 / 399
页数：6
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