The Protective Effect of Semax in a Model of Stress-Induced Impairment of Memory and Behavior in White Rats

被引：6

作者：

Glazova, N. Yu. ^{[1
]}

Sebentsova, E. A. ^{[1
]}

Manchenko, D. M. ^{[2
]}

Andreeva, L. A. ^{[1
]}

Dergunova, L. V. ^{[1
]}

Levitskaya, N. G. ^{[1
,2
]}

Limborska, S. A. ^{[1
]}

Myasoedov, N. F. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia

[2] Moscow MV Lomonosov State Univ, Fac Biol, Moscow 119992, Russia

来源：

BIOLOGY BULLETIN | 2018年 / 45卷 / 04期

基金：

俄罗斯科学基金会;

关键词：

ACUTE RESTRAINT STRESS; ACTH(4-10) ANALOG; SPATIAL MEMORY; FEMALE RATS; PRETREATMENT; RECOGNITION; HIPPOCAMPUS; EXPERIENCE; ANXIETY; SYSTEMS;

D O I：

10.1134/S1062359018040040

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effect of acute restrained stress on cognitive functions and anxiety-like behavior in white rats has been studied; furthermore, the influence of the fragment ACTH(4-10) analog Semax on the stress effects was evaluated. It was shown that stress exposure leads to impaired retention of previously acquired food-motivated maze task as well as reduced anxiety-like behavior in the elevated plus maze in rats. Preliminary intraperitonial administration of Semax (0.1 mg/kg) attenuates cognitive impairment caused by acute restrained stress, but it does not affect stress-induced changes in anxiety.

引用

页码：394 / 399

页数：6

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