Implementing a Personalized Antimicrobial Stewardship Program for Women with Gynecological Cancers and Healthcare-Associated Infections

被引:0
作者
Di Giambenedetto, Simona [1 ,2 ]
Borghetti, Alberto [1 ]
Quagliozzi, Lorena [3 ]
Gallucci, Valeria [3 ]
Lombardi, Francesca [2 ]
Ciccullo, Arturo [4 ]
Fagotti, Anna [3 ]
Tamburrini, Enrica [1 ]
Scambia, Giovanni [3 ]
机构
[1] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Lab Infettivol, UOC Malattie Infett, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Dipartimento Sicurezza & Bioet, Sez Malattie Infett, I-00168 Rome, Italy
[3] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Salute Donna Bambino & San Pubbl, UOC Ginecol Oncol, I-00168 Rome, Italy
[4] Osped San Salvatore, UOC Malattie Infett, I-67100 Laquila, Italy
来源
JOURNAL OF PERSONALIZED MEDICINE | 2022年 / 12卷 / 04期
关键词
gynecologic oncology; personalized medicine; healthcare-associated infections; antimicrobial stewardship; OPAT; ENHANCED RECOVERY; DISEASES SOCIETY; ONCOLOGY; SURGERY; AMERICA; IMPACT;
D O I
10.3390/jpm12040650
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Healthcare-associated infections (HCAIs) represent a major cause of morbidity and mortality in gynecologic cancer patients, requiring personalized cures. A retrospective study on gynecologic patients with HCAIs, managed through an antimicrobial stewardship program, was performed, focusing on rates of clinical cure, breakthrough/relapse of infections, death, and time of hospital stay (THS). In total, 27 patients (median 60 years, mainly suffering from ovarian, cervical, and uterine cancer) were evaluated by a specialist in infectious diseases and were mainly diagnosed with complicated urinary tract (cUTIs, 12 cases, 44.4%) and bloodstream infections (BSIs, 9 cases, 33.3%). A total of 15 cases (11 cUTIs, 73.3%) were managed with no need for hospitalization and received a median of 11 days of outpatient parenteral antimicrobial therapy (OPAT). In the remaining 12 cases (BSIs in 8 cases, 66.7%), the median THS was 11 days, with 15 days median overall duration of antimicrobial therapy (median 5-day reduction in THS). The management of patients also included source control and wound care. All patients reached clinical cure, with no case of breakthrough infection, one case of relapse, and one death within 30 days (not attributable to the infection). HCAIs in patients with gynecologic tumors can be managed through a patient-centered, multidisciplinary antimicrobial stewardship program.
引用
收藏
页数:8
相关论文
共 18 条
  • [1] Are patients with cancer with sepsis and bacteraemia at a higher risk of mortality? A retrospective chart review of patients presenting to a tertiary care centre in Lebanon
    Abou Dagher, Gilbert
    El Khuri, Christopher
    Chehadeh, Ahel Al-Hajj
    Chami, Ali
    Bachir, Rana
    Zebian, Dina
    Chebl, Ralphe Bou
    [J]. BMJ OPEN, 2017, 7 (03):
  • [2] Infectious diseases in gynecologic oncology - An overview
    Adam, RA
    Adam, YG
    [J]. OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA, 2001, 28 (04) : 847 - +
  • [3] Outpatient parenteral antimicrobial therapy with ceftriaxone for acute tonsillopharyngitis: efficacy, patient satisfaction, cost effectiveness, and safety
    Al Alawi, Samah
    Abdulkarim, Somaya
    Elhennawy, Hazem
    Al-Mansoor, Anwar
    Al Ansari, Ahmed
    [J]. INFECTION AND DRUG RESISTANCE, 2015, 8 : 279 - 285
  • [4] Barlam TF, 2016, CLIN INFECT DIS, V62, pE51, DOI 10.1093/cid/ciw118
  • [5] Outcomes of enhanced recovery after surgery (ERAS) in gynecologic oncology ? A systematic review and meta-analysis.
    Bisch, S. P.
    Jago, C. A.
    Kalogera, E.
    Ganshorn, H.
    Meyer, L. A.
    Ramirez, P. T.
    Dowdy, S. C.
    Nelson, G.
    [J]. GYNECOLOGIC ONCOLOGY, 2021, 161 (01) : 46 - 55
  • [6] Building a Personalized Medicine Infrastructure for Gynecological Oncology Patients in a High-Volume Hospital
    Bizzarri, Nicolo
    Nero, Camilla
    Sillano, Francesca
    Ciccarone, Francesca
    D'Oria, Marika
    Cesario, Alfredo
    Fragomeni, Simona Maria
    Testa, Antonia Carla
    Fanfani, Francesco
    Ferrandina, Gabriella
    Lorusso, Domenica
    Fagotti, Anna
    Scambia, Giovanni
    [J]. JOURNAL OF PERSONALIZED MEDICINE, 2022, 12 (01):
  • [7] Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis
    Cassini, Alessandro
    Hogberg, Liselotte Diaz
    Plachouras, Diamantis
    Quattrocchi, Annalisa
    Hoxha, Ana
    Simonsen, Gunnar Skov
    Colomb-Cotinat, Melanie
    Kretzschmar, Mirjam E.
    Devleesschauwer, Brecht
    Cecchini, Michele
    Ouakrim, Driss Ait
    Oliveira, Tiago Cravo
    Struelens, Marc J.
    Suetens, Carl
    Monnet, Dominique L.
    Strauss, Reinhild
    Mertens, Karl
    Struyf, Thomas
    Catry, Boudewijn
    Latour, Katrien
    Ivanov, Ivan Nikolaev
    Dobreva, Elina Georgieva
    Tambic Andrasevic, Arjana
    Soprek, Silvija
    Budimir, Ana
    Paphitou, Niki
    Zemlickova, Helena
    Olsen, Stefan Schytte
    Sonksen, Ute Wolff
    Martin, Pille
    Ivanova, Marina
    Lyytikainen, Outi
    Jalava, Jari
    Coignard, Bruno
    Eckmanns, Tim
    Abu Sin, Muna
    Haller, Sebastian
    Daikos, George L.
    Gikas, Achilleas
    Tsiodras, Sotirios
    Kontopidou, Flora
    Toth, Akos
    Hajdu, Agnes
    Guolaugsson, Olafur
    Kristinsson, Karl G.
    Murchan, Stephen
    Burns, Karen
    Dsstat, Patrizio Pezzotti
    Gagliotti, Carlo
    Dumpis, Uga
    [J]. LANCET INFECTIOUS DISEASES, 2019, 19 (01) : 56 - 66
  • [8] Outpatient parenteral antimicrobial therapy (OPAT) versus inpatient care in the UK: a health economic assessment for six key diagnoses
    Dimitrova, Maria
    Gilchrist, Mark
    Seaton, R. A.
    [J]. BMJ OPEN, 2021, 11 (09):
  • [9] Risk factors for bloodstream infections in gynecological cancer
    Franza, Laura
    Costantini, Barbara
    Corrado, Giacomo
    Spanu, Teresa
    Covino, Marcello
    Ojetti, Veronica
    Quagliozzi, Lorena
    Biscione, Antonella
    Taccari, Francesco
    Fagotti, Anna
    Scambia, Giovanni
    Tamburrini, Enrica
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2020, 30 (02) : 245 - 251
  • [10] Grant MC, 2017, ANN SURG, V265, P68, DOI [10.1097/sla.0000000000001703, 10.1097/SLA.0000000000001703]