Prolactinomas

被引:153
作者
Klibanski, Anne [1 ,2 ]
机构
[1] Massachusetts Gen Hosp, Neuroendocrine Unit, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
关键词
TERM-FOLLOW-UP; VALVULAR HEART-DISEASE; SECRETING PITUITARY-ADENOMAS; CARDIAC-VALVE REGURGITATION; DOPAMINE AGONISTS; CABERGOLINE THERAPY; HYPERPROLACTINEMIC AMENORRHEA; TRANSSPHENOIDAL SURGERY; BROMOCRIPTINE; WITHDRAWAL;
D O I
10.1056/NEJMcp0912025
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 42-year-old man presents with decreased libido, erectile dysfunction, and headaches. He reports no weight change, gynecomastia, fatigue, or other symptoms. He takes no medications. Testicular size is decreased on examination. His prolactin level is 648 mu g per liter (normal value, <15). Magnetic resonance imaging (MRI) reveals a sellar mass (2.5 by 1.5 by 2.0 cm) that is 5 mm below the optic chiasm and that extends bilaterally into the cavernous sinuses. What are the diagnostic and therapeutic considerations?
引用
收藏
页码:1219 / 1226
页数:8
相关论文
共 51 条
[1]   Clinical profile and long term follow up of children and adolescents with prolactinomas [J].
Acharya, Shrikrishna V. ;
Gopal, Raju A. ;
Bandgar, Tushar R. ;
Joshi, Shashank R. ;
Menon, Padma S. ;
Shah, Nalini S. .
PITUITARY, 2009, 12 (03) :186-189
[2]   Transsphenoidal surgery for pituitary tumors in the United States, 1996-2000: Mortality, morbidity, and the effects of hospital and surgeon volume [J].
Barker, FG ;
Klibanski, A ;
Swearingen, B .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (10) :4709-4719
[3]   PULSATILE GNRH THERAPY - AN ALTERNATIVE SUCCESSFUL THERAPY FOR INDUCTION OF OVULATION IN INFERTILE NORMOPROLACTINAEMIC AND HYPERPROLACTINAEMIC AMENORRHEIC WOMEN WITH PITUITARY-TUMORS [J].
BERGH, T ;
SKARIN, G ;
NILLIUS, SJ ;
WIDE, L .
ACTA ENDOCRINOLOGICA, 1985, 110 (04) :440-444
[4]   Treatment of prolactin-secreting macroadenomas with the once-weekly dopamine agonist cabergoline [J].
Biller, BMK ;
Molitch, ME ;
Vance, ML ;
Cannistraro, KB ;
Davis, KR ;
Simons, JA ;
Schoenfelder, JR ;
Klibanski, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (06) :2338-2343
[5]   Long-term remission following withdrawal of dopamine agonist therapy in subjects with microprolactinomas [J].
Biswas, M ;
Smith, J ;
Jadon, D ;
McEwan, P ;
Rees, DA ;
Evans, LM ;
Scanlon, MF ;
Davies, JS .
CLINICAL ENDOCRINOLOGY, 2005, 63 (01) :26-31
[6]   Cabergoline therapy and the risk of cardiac valve regurgitation in patients with hyperprolactinemia: A meta-analysis from clinical studies [J].
Bogazzi, F. ;
Manetti, L. ;
Raffaelli, V. ;
Lombardi, M. ;
Rossi, G. ;
Martino, E. .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2008, 31 (12) :1119-1123
[7]   PROLACTIN-SECRETING TUMORS AND HYPOGONADISM IN 22 MEN [J].
CARTER, JN ;
TYSON, JE ;
TOLIS, G ;
VANVLIET, S ;
FAIMAN, C ;
FRIESEN, HG .
NEW ENGLAND JOURNAL OF MEDICINE, 1978, 299 (16) :847-852
[8]   Guidelines of the Pituitary Society for the diagnosis and management of prolactinomas [J].
Casanueva, Felipe F. ;
Molitch, Mark E. ;
Schlechte, Janet A. ;
Abs, Roger ;
Bonert, Vivien ;
Bronstein, Marcello D. ;
Brue, Thierry ;
Cappabianca, Paolo ;
Colao, Annamaria ;
Fahlbusch, Rudolf ;
Fideleff, Hugo ;
Hadani, Moshe ;
Kelly, Paul ;
Kleinberg, David ;
Laws, Edward ;
Marek, Josef ;
Scanlon, Maurice ;
Sobrinho, Luis G. ;
Wass, John A. H. ;
Giustina, Andrea .
CLINICAL ENDOCRINOLOGY, 2006, 65 (02) :265-273
[9]   Withdrawal of long-term cabergoline therapy for tumoral and nontumoral hyperprolactinemia [J].
Colao, A ;
Di Sarno, A ;
Cappabianca, P ;
Di Somma, C ;
Pivonello, R ;
Lombardi, G .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (21) :2023-2033
[10]   Prolactinomas resistant to standard dopamine agonists respond to chronic cabergoline treatment [J].
Colao, A ;
DiSarno, A ;
Sarnacchiaro, F ;
Ferone, D ;
DiRenzo, G ;
Merola, B ;
Annunziato, L ;
Lombardi, G .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (03) :876-883