Advances in neonatal screening for primary immune deficiencies

被引：4
作者：
Jiang, Tingting [1 ]
Li, Zhenguang [1 ]
Zhang, Qiuli [1 ]
机构：
[1] Xuzhou Childrens Hosp, Dept Neonatol, 18 Sudibei Rd, Xuzhou 221002, Jiangsu, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2016年 / 11卷 / 05期
关键词：
primary immunodeficiencies; neonate screening; immune competence; SEVERE COMBINED IMMUNODEFICIENCY; COMMON VARIABLE IMMUNODEFICIENCY; IDENTIFICATION; ANTIBODIES; THERAPY; SYSTEM;
D O I：
10.3892/etm.2016.3119
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The congenital disorders of immune competence are known as primary immunodeficiencies (PID) and are mainly characterized by a pathological susceptibility to infection. These infections are mostly of time repetitive and drug resistant in nature. The number of infected infants has reached over 200 and is on the increase. Additionally, clinical severity of the disease has been confirmed to be extensive. The increasing number of these severe PIDs is due to the lack of specific as well as efficient management avenues. New assays and concepts for newborn screening of severe primary immune deficiencies are being explored and the present review focused on these new upcoming strategies for improved screening of neonates.
引用
收藏
页码：1542 / 1544
页数：3
相关论文
共 25 条
  • [1] Comparison of pulmonary diseases in common variable immunodeficiency and X-linked agammaglobulinaemia
    Aghamohammadi, Asghar
    Allahverdi, Abdolreza
    Abolhassani, Hassan
    Moazzami, Kasra
    Alizadeh, Hooman
    Gharagozlou, Mohammad
    Kalantari, Najmoddin
    Sajedi, Vahid
    Shafiei, Alireza
    Parvaneh, Nima
    Mohammadpour, Masoud
    Karimi, Nasser
    Sadaghiani, Mohammad Salehi
    Rezaei, Nima
    [J]. RESPIROLOGY, 2010, 15 (02) : 289 - 295
  • [2] Primary immunodeficiency diseases: an update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency
    Al-Herz, Waleed
    Bousfiha, Aziz
    Casanova, Jean-Laurent
    Chatila, Talal
    Conley, Mary Ellen
    Cunningham-Rundles, Charlotte
    Etzioni, Amos
    Franco, Jose Luis
    Gaspar, H. Bobby
    Holland, Steven M.
    Klein, Christoph
    Nonoyama, Shigeaki
    Ochs, Hans D.
    Oksenhendler, Erik
    Picard, Capucine
    Puck, Jennifer M.
    Sullivan, Kate
    Tang, Mimi L. K.
    [J]. FRONTIERS IN IMMUNOLOGY, 2014, 5
  • [3] Severe combined immunodeficiency (SCID) and rotavirus vaccination: Reports to the Vaccine Adverse Events Reporting System (VAERS)
    Bakare, Nyasha
    Menschik, David
    Tiernan, Rosemary
    Hua, Wei
    Martin, David
    [J]. VACCINE, 2010, 28 (40) : 6609 - 6612
  • [4] Therapeutic Implications of the IL-21: IL-4 Receptor System in Children with Common Variable Immunodeficiency Syndrome
    Borte, S.
    Lanig, H.
    Borte, M.
    Fasshauer, M.
    Sack, U.
    [J]. KLINISCHE PADIATRIE, 2010, 222 (06): : 362 - 367
  • [5] Guidelines for newborn screening of primary immunodeficiency diseases
    Borte, Stephan
    von Dobelin, Ulrika
    Hammarstrom, Lennart
    [J]. CURRENT OPINION IN HEMATOLOGY, 2013, 20 (01) : 48 - 54
  • [6] Newborn screening for primary immunodeficiencies: beyond SCID and XLA
    Borte, Stephan
    Wang, Ning
    Oskarsdottir, Solveig
    von Dobeln, Ulrika
    Hammarstrom, Lennart
    [J]. YEAR IN HUMAN AND MEDICAL GENETICS: INBORN ERRORS OF IMMUNITY II, 2011, 1246 : 118 - 130
  • [7] Neonatal diagnosis of severe combined immunodeficiency leads to significantly improved survival outcome: the case for newborn screening
    Brown, Lucinda
    Xu-Bayford, Jinhua
    Allwood, Zoe
    Slatter, Mary
    Cant, Andrew
    Davies, E. Graham
    Veys, Paul
    Gennery, Andrew R.
    Gaspar, H. Bobby
    [J]. BLOOD, 2011, 117 (11) : 3243 - 3246
  • [8] Cavazzana-Calvo M, 2012, CURR OPIN IMMUNOL, V24, P580, DOI 10.1016/j.coi.2012.08.008
  • [9] A Markov model to analyze cost-effectiveness of screening for severe combined immunodeficiency (SCID)
    Chan, Kee
    Davis, Joie
    Pai, Sung-Yun
    Bonilla, Francisco A.
    Puck, Jennifer M.
    Apkon, Michael
    [J]. MOLECULAR GENETICS AND METABOLISM, 2011, 104 (03) : 383 - 389
  • [10] Method Designed to Respect Molecular Heterogeneity Can Profoundly Correct Present Data Interpretations for Genome-Wide Expression Analysis
    Chen, Chih-Hao
    Hsu, Chueh-Lin
    Huang, Shih-Hao
    Chen, Shih-Yuan
    Hung, Yi-Lin
    Chen, Hsiao-Rong
    Wu, Yu-Chung
    Su, Li-Jen
    Lee, H. C.
    [J]. PLOS ONE, 2015, 10 (03):
123