DNA fragments induction in human fibroblasts by radiations of different qualities

被引：13

作者：

Esposito, G.

Belli, M.

Campa, A.

Cherubini, R.

Cuttone, G.

Dini, V.

Furusawa, Y.

Gerardi, S.

Simone, G.

Sorrentino, E.

Tabocchini, M. A.

机构：

[1] Ist Super Sanita, Hlth & Technol Dept, I-00161 Rome, Italy

[2] Ist Nazl Fis Nucl, Sez Roma 1, Grp Collegato Sanita, Rome, Italy

[3] Ist Nazl Fis Nucl, Lab Nazl Legnaro, I-35020 Legnaro, Italy

[4] Ist Nazl Fis Nucl, Lab Nazl Sud, I-95129 Catania, Italy

[5] Natl Inst Radiol Sci, Chiba 260, Japan

来源：

RADIATION PROTECTION DOSIMETRY | 2006年 / 122卷 / 1-4期

关键词：

D O I：

10.1093/rpd/ncl389

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Experimental data on DNA double strand break (DSB) induction in human fibroblasts (AG1522), following irradiation with several radiation qualities, namely gamma rays, 0.84 MeV protons, 58.9 Mev u(-1) carbon ions, iron ions of 115 MeV u(-1), 414 MeV u(-1), 1 GeV u(-1), and 5 GeV u(-1), are presented. DSB yields were measured by calibrated Pulsed Field Gel Electrophoresis in the DNA fragment size range 0.023-5.7 Mbp. The DSB yields show little LET dependence, in spite of the large variation of the latter among the beams, and are slightly higher than that obtained using gamma rays. The highest yield was found for the 5 GeV u(-1) iron beam, that gave a value 30% higher than the 1 GeV u(-1) iron beam. A phenomenological method is used to parametrise deviation from randomness in fragment size spectra.

引用

页码：166 / 168

页数：3

共 6 条

[1] DNA fragmentation in V79 cells irradiated with light ions as measured by pulsed-field gel electrophoresis. I. Experimental results [J].