Cell therapy of critical limb ischemia-problems and prospects

被引：12

作者：

Osipova, Olesia ^{[1
]}

Saaya, Shoraan ^{[1
]}

Karpenko, Andrei ^{[1
]}

Zakian, Suren ^{[1
]}

Aboian, Edouard ^{[2
]}

机构：

[1] Meshalkin Natl Med Res Ctr, Dachnaya St 21-1,33, Novosibirsk 630082, Russia

[2] Palo Alto Med Fdn, Div Vasc Surg, Burlingame, CA USA

来源：

VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE | 2019年 / 48卷 / 06期

关键词：

Angiogenesis; bone marrow stem cells; cell therapy; critical lower limb ischemia; peripheral vascular disease; ENDOTHELIAL PROGENITOR CELLS; MESENCHYMAL STEM-CELLS; MARROW-MONONUCLEAR-CELLS; COLONY-STIMULATING FACTOR; PERIPHERAL ARTERY-DISEASE; UMBILICAL-CORD BLOOD; DOUBLE-BLIND; GENE-THERAPY; AUTOLOGOUS TRANSPLANTATION; INTERMITTENT CLAUDICATION;

D O I：

10.1024/0301-1526/a000787

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Cell therapy is proposed for indirect revascularization for the patient's incurable by endovascular or surgical revascularization. The therapy with stem cells (SCs) or progenitor cells is assumed to be more efficient as compared with protein or gene therapy not only because of their direct vasculogenic properties, but also thanks to their paracrine effect via secretion of manifold biologically active substances. This review gives an overview of the potential of SC-based therapy for critical limb ischemia (CLI), putative mechanism underlying cell therapy, and comparison of cell therapy to angiogenesis gene therapy in CLI treatment. Human trial data and meta-analysis, as well as some problems of clinical trials and considerations for future SC-based therapy in CLI are also discussed.

引用

页码：461 / 471

页数：11

共 76 条

[1] Safety and efficacy of cell-based therapy on critical limb ischemia: A meta-analysis [J].

Ai, Min ;

Yan, Chang-Fu ;

Xia, Fu-Chun ;

Zhou, Shuang-Lu ;

He, Jian ;

Li, Cui-Ping .

CYTOTHERAPY, 2016, 18 (06) :712-724

[2] Harnessing the Angiogenic Potential of Stem Cell-Derived Exosomes for Vascular Regeneration [J].

Alcayaga-Miranda, F. ;

Varas-Godoy, M. ;

Khoury, M. .

STEM CELLS INTERNATIONAL, 2016, 2016

[3] Design and rationale of a randomized, double-blind, placebo-controlled phase III study for autologous bone marrow cell transplantation in critical limb ischemia: the BONe Marrow Outcomes Trial in Critical Limb Ischemia (BONMOT-CLI) [J].

Amann, B. ;

Luedemann, C. ;

Rueckert, R. ;

Lawall, H. ;

Liesenfeld, B. ;

Schneider, M. ;

Schmidt-Lucke, J. .

VASA-JOURNAL OF VASCULAR DISEASES, 2008, 37 (04) :319-325

[4] Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization [J].

Asahara, T ;

Masuda, H ;

Takahashi, T ;

Kalka, C ;

Pastore, C ;

Silver, M ;

Kearne, M ;

Magner, M ;

Isner, JM .

CIRCULATION RESEARCH, 1999, 85 (03) :221-228

[5] Concise Review: Circulating Endothelial Progenitor Cells for Vascular Medicine [J].

Asahara, Takayuki ;

Kawamoto, Atsuhiko ;

Masuda, Haruchika .

STEM CELLS, 2011, 29 (11) :1650-1655

[6] The Aastrom experience [J].

Bartel, Ronnda L. ;

Cramer, Caryn ;

Ledford, Kelly ;

Longcore, Amy ;

Parrish, Christopher ;

Stern, Theresa ;

Watling, Sharon ;

Zeigler, Frank .

STEM CELL RESEARCH & THERAPY, 2012, 3

[7] Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia [J].

Belch, Jill ;

Hiatt, William R. ;

Baumgartner, Iris ;

Driver, I. Vickie ;

Nikol, Sigrid ;

Norgren, Lars ;

Van Belle, Eric .

LANCET, 2011, 377 (9781) :1929-1937

[8] Allogeneic transplantation of programmable cells of monocytic origin (PCMO) improves angiogenesis and tissue recovery in critical limb ischemia (CLI): a translational approach [J].

Berndt, Rouven ;

Hummitzsch, Lars ;

Hess, Katharina ;

Albrecht, Martin ;

Zitta, Karina ;

Rusch, Rene ;

Sarras, Beke ;

Bayer, Andreas ;

Cremer, Jochen ;

Faendrich, Fred ;

Gross, Justus .

STEM CELL RESEARCH & THERAPY, 2018, 9

[9] Expansion and angiogenic potential of mesenchymal stem cells from patients with critical limb ischemia [J].

Brewster, Luke ;

Robinson, Scott ;

Wang, Ruoya ;

Griffiths, Sarah ;

Li, Haiyan ;

Peister, Alexandra ;

Copland, Ian ;

McDevitt, Todd .

JOURNAL OF VASCULAR SURGERY, 2017, 65 (03) :826-+

[10] Phase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia [J].

Bura, Alessandra ;

Planat-Benard, Valerie ;

Bourin, Philippe ;

Silvestre, Jean-Sebastien ;

Gross, Fabian ;

Grolleau, Jean-Louis ;

Saint-Lebese, Bertrand ;

Peyrafitte, Julie-Anne ;

Fleury, Sandrine ;

Gadelorge, Melanie ;

Taurand, Marion ;

Dupuis-Coronas, Sophie ;

Leobon, Bertrand ;

Casteilla, Louis .

CYTOTHERAPY, 2014, 16 (02) :245-257

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