The use of spirocyclic scaffolds in drug discovery

被引：837

作者：

Zheng, Yajun ^{[1
]}

Tice, Colin M. ^{[1
]}

Singh, Suresh B. ^{[1
]}

机构：

[1] Vitae Pharmaceut Inc, Ft Washington, PA 19034 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 16期

关键词：

Spirocyclic; Scaffold; Drug discovery; 1; BACE1; INHIBITORS; MACROCYCLIC INHIBITORS; UREA DERIVATIVES; RECEPTOR LIGANDS; INVERSE AGONISTS; POTENT; DESIGN; OPTIMIZATION; BETA; IDENTIFICATION;

D O I：

10.1016/j.bmcl.2014.06.081

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Owing to their inherent three-dimensionality and structural novelty, spiro scaffolds have been increasingly utilized in drug discovery. In this brief review, we highlight selected examples from the primary medicinal chemistry literature during the last three years to demonstrate the versatility of spiro scaffolds. With recent progress in synthetic methods providing access to spiro building blocks, spiro scaffolds are likely to be used more frequently in drug discovery. (C) 2014 The Authors. Published by Elsevier Ltd.

引用

页码：3673 / 3682

页数：10

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