Hepatitis C Infection and Related Factors in Hemodialysis Patients in China: Systematic Review and Meta-Analysis

被引:48
作者
Sun, Jinghua [1 ]
Yu, Rongbin [2 ]
Zhu, Bei [1 ]
Wu, Jianqing [1 ]
Larsen, Steven [3 ]
Zhao, Weihong [1 ]
机构
[1] Nanjing Med Univ, Dept Geriatr, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing 210029, Jiangsu, Peoples R China
[3] Indiana Univ, Sch Med, Dept Microbiol Immunol, Indianapolis, IN 46202 USA
关键词
hepatitis C virus; hemodialysis; meta-analysis; enzyme immunoassay (EIA); Chinese; VIRUS-INFECTION; RISK-FACTORS; DIALYSIS; EPIDEMIOLOGY; PREVALENCE; TRANSMISSION; RECIPIENTS; MEMBRANE; DISEASES;
D O I
10.1080/08860220903003446
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background and Aims. To provide a comprehensive and reliable tabulation of available data on the epidemiological characteristics and risk factors for hepatitis C virus (HCV) infection in maintenance hemodialysis (HD) patients in China, and to help inform prevention programs and guide future research. Methods. A systematic review was constructed based on the computerized literature database by two reviewers independently. Ninety-five percent confidence intervals (CI) of infection rates were calculated using the approximate normal distribution model. Odds ratios and 95% CI were calculated by fixed or random effects models. Results. Forty-three studies met our inclusion criteria. The pooled prevalence of HCV infection among HD patients in China was 41.1% (95% CI 39.5-42.6%). No significant difference was found in HCV infection rates between male and female HD patients (OR = 0.75, 95% CI 0.52-1.07, p = 0.11). HD patients with blood transfusion were 5.65 times more likely to be infected with HCV than HD patients without blood transfusion. A longer duration of HD was associated with increased HCV prevalence. Co-infection with hepatitis B virus did not increase the probability of HCV infection among HD patients (OR = 1.19, 95% CI 0.34-3.20, p = 0.73). Conclusions. Viral hepatitis is still one of the main complications in HD patients, with hepatitis C being the most common one. The key to reducing the incidence of viral hepatitis in HD patients is to control contagion and reduce the frequency of blood transfusion and cross-infection.
引用
收藏
页码:610 / 620
页数:11
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