Contribution of BlaA and BlaB β-Lactamases to Antibiotic Susceptibility of Yersinia enterocolitica Biovar 1B

被引：26

作者：

Bent, Zachary W. ^{[2
]}

Young, Glenn M. ^{[1
,2
]}

机构：

[1] Univ Calif Davis, Dept Food Sci & Technol, Davis, CA 95616 USA

[2] Univ Calif Davis, Microbiol Grad Grp, Davis, CA 95616 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 09期

基金：

美国国家卫生研究院;

关键词：

NUCLEOTIDE-SEQUENCE; IN-VITRO; GENES; 1A; CHROMOSOME; EXPRESSION; STRAINS;

D O I：

10.1128/AAC.01754-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Highly pathogenic Yersinia enterocolitica biovar 1B produces two distinct beta-lactamases, BlaA and BlaB. Mutants of a representative biovar 1B isolate were constructed and evaluated to determine the extent of limitation of susceptibility to broad-spectrum beta-lactam antibiotics by BlaA and BlaB. The results demonstrated that BlaA, a class A enzyme, plays a significant role in limiting susceptibility to penicillins and cephalosporins. The contribution of BlaB, a class C enzyme, was less profound and was limited primarily to cephalosporin susceptibility.

引用

页码：4000 / 4002

页数：3

共 21 条

[1] Yersinia enterocolitica:: overview and epidemiologic correlates [J].

Bottone, EJ .

MICROBES AND INFECTION, 1999, 1 (04) :323-333

[2] Characterization of defective β-lactamase genes in Yersinia enterocolitica [J].

Carmen de la Prieta, Maria ;

Francia, Maria Victoria ;

Seoane, Asuncion ;

Garcia Lobo, Juan M. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (03) :661-664

[3] BETA-LACTAMASES FROM YERSINIA-ENTEROCOLITICA [J].

CORNELIS, G ;

ABRAHAM, EP .

JOURNAL OF GENERAL MICROBIOLOGY, 1975, 87 (APR) :273-284

[4] YERSINIA-ENTEROCOLITICA [J].

COVER, TL ;

ABER, RC .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (01) :16-24

[5] Expression analysis of the yersiniabactin receptor gene fyuA and the heme receptor hemR of Yersinia enterocolitica in vitro and in vivo using the reporter genes for green fluorescent protein and luciferase [J].

Jacobi, CA ;

Gregor, S ;

Rakin, A ;

Heesemann, J .

INFECTION AND IMMUNITY, 2001, 69 (12) :7772-7782

[6] CLONING OF THE YENI RESTRICTION-ENDONUCLEASE AND METHYLTRANSFERASE FROM YERSINIA-ENTEROCOLITICA SEROTYPE O8 AND CONSTRUCTION OF A TRANSFORMABLE R(-)M(+) MUTANT [J].

KINDER, SA ;

BADGER, JL ;

BRYANT, GO ;

PEPE, JC ;

MILLER, VL .

GENE, 1993, 136 (1-2) :271-275

[7] Population-based incidence of infection with selected bacterial enteric pathogens in children younger than five years of age, 1996-1998 [J].

Koehler, KM ;

Lasky, T ;

Fein, SB ;

DeLong, SM ;

Hawkins, MA ;

Rabatsky-Ehr, T ;

Ray, SM ;

Shiferaw, B ;

Swanson, E ;

Vugia, DJ .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2006, 25 (02) :129-134

[8] NOVEL METHOD FOR DETECTION OF BETA-LACTAMASES BY USING A CHROMOGENIC CEPHALOSPORIN SUBSTRATE [J].

OCALLAGHAN, CH ;

SHINGLER, AH ;

KIRBY, SM ;

MORRIS, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1972, 1 (04) :283-+

[9] THE PREVALENCE OF INDUCIBLE BETA-LACTAMASE IN CLINICAL ISOLATES OF YERSINIA-ENTEROCOLITICA [J].

PHAM, JN ;

BELL, SM .

PATHOLOGY, 1993, 25 (04) :385-387

[10] A STUDY OF THE BETA-LACTAMASES OF 100 CLINICAL ISOLATES OF YERSINIA-ENTEROCOLITICA [J].

PHAM, JN ;

BELL, SM ;

LANZARONE, JYM .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1991, 28 (01) :19-24

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