miR-26a suppresses tumour proliferation and metastasis by targeting metadherin in triple negative breast cancer

被引：107
作者：
Liu, Peng [1 ]
Tang, Hailin [1 ]
Chen, Bo [1 ]
He, Zhimin [2 ,3 ]
Deng, Min [2 ,3 ]
Wu, Minqing [4 ]
Liu, Xiaoping [1 ]
Yang, Lu [1 ]
Ye, Feng [1 ]
Xie, Xiaoming [1 ]
机构：
[1] Sun Yat Sen Univ Canc Ctr, Dept Breast Oncol, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R China
[4] Sun Yat Sen Univ Canc, Dept Canc Prevent Ctr, Guangzhou, Guangdong, Peoples R China
来源：
CANCER LETTERS | 2015年 / 357卷 / 01期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
miR-26a; Triple negative breast cancer; MTDH; EPITHELIAL-MESENCHYMAL TRANSITION; MICRORNA EXPRESSION; LIVER-CANCER; LUNG-CANCER; CELL-GROWTH; CARCINOMA; IDENTIFICATION; PROGRESSION; MIGRATION; PROFILES;
D O I：
10.1016/j.canlet.2014.11.050
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It has been reported that miR-26a plays an important role in various cancers. In this study, we found that miR-26a was downregulated in triple-negative breast cancer (TNBC), and its expression levels were associated with lymph node metastasis and overall survival in TNBC. We also found that the ectopic expression of miR-26a inhibited TNBC cell proliferation and metastasis in vitro and in vivo by downregulating MTDH (a miR-26a' target gene) mRNA and protein and that the overexpression of MTDH could partially abrogate miR-26a-mediated suppression. Our data suggest that miR-26a functions as a tumour suppressor in TNBC development and serves as a prognostic marker for breast cancer. (c) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：384 / 392
页数：9
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