Clinical characteristics and prognostic factors of malignant tumors involving pterygopalatine fossa

被引：8
作者：
Woo, Hyun-Jae [1 ,2 ]
Hwang, Peter H. [2 ]
Kaplan, Michael J. [2 ]
Choby, Garret [2 ,3 ]
机构：
[1] CHA Univ, Gumi CHA Hosp, Dept Otolaryngol Head & Neck Surg, Sch Med, Gumi, South Korea
[2] Stanford Univ, Dept Otolaryngol Head & Neck Surg, Sch Med, Stanford, CA USA
[3] Mayo Clin, Dept Otolaryngol Head & Neck Surg, Coll Med, 200 First St SW, Rochester, MN 55905 USA
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2020年 / 42卷 / 02期
关键词：
malignant tumor; maxillary nerve; perineural invasion; prognosis; pterygopalatine fossa; ADENOID CYSTIC CARCINOMA; PERINEURAL INVASION; INFRATEMPORAL FOSSA; SKIN-CANCER; HEAD; NECK; SPREAD;
D O I：
10.1002/hed.26000
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background To identify the clinical characteristics and prognostic factors of malignancies involving the pterygopalatine fossa (PPF). Methods Fifty-seven patients who underwent curative surgery for malignant tumor involving PPF were reviewed. Results The rates for three-year local control (LC), five-year disease-free survival (DFS) and five-year overall survival (OS) were 55.4%, 34.5%, and 52.7%, respectively. Perineural invasion (PNI) of the maxillary nerve with facial numbness (symptomatic V2 PNI) (P = .04) and cranial involvement (P = .03) were predictors for poor OS. Symptomatic V2 PNI was also a significant predictor for poor LC (P = .05) and DFS (P = .03). Within the subgroup analysis of patients with pathologically confirmed V2 PNI, asymptomatic V2 PNI patients had significantly better LC (71.2% vs 31.8%, P = .05) and DFS (43.8% vs 17.3%, P = .05) compared to symptomatic patients. Conclusion Malignant tumors involving the PPF have diverse pathologies and a poor prognosis. Symptomatic V2 PNI may be an independent poor prognostic factor.
引用
收藏
页码：281 / 288
页数：8
相关论文
共 20 条
[1]   Long-Term Local Control Rates of Patients With Adenoid Cystic Carcinoma of the Head and Neck Managed by Surgery and Postoperative Radiation [J].
Ali, Safina ;
Palmer, Frank L. ;
Katabi, Nora ;
Lee, Nancy ;
Shah, Jatin P. ;
Patel, Snehal G. ;
Ganly, Ian .
LARYNGOSCOPE, 2017, 127 (10) :2265-2269
[2]   Design and rationale of a prospective, multi-institutional registry for patients with sinonasal malignancy [J].
Beswick, Daniel M. ;
Holsinger, F. Christopher ;
Kaplan, Michael J. ;
Fischbein, Nancy J. ;
Hara, Wendy ;
Colevas, A. Dimitrios ;
Quynh-Thu Le ;
Berry, Gerald J. ;
Hwang, Peter H. .
LARYNGOSCOPE, 2016, 126 (09) :1977-1980
[3]  
Chan LL, 2000, AM J NEURORADIOL, V21, P1315
[4]   Imaging of perineural tumor spread in head and neck cancer [J].
Ginsberg, LE .
SEMINARS IN ULTRASOUND CT AND MRI, 1999, 20 (03) :175-186
[5]   Outcome of resection of infratemporal fossa tumors [J].
Givi, Babak ;
Liu, Jeffrey ;
Bilsky, Mark ;
Mehrara, Babak ;
Disa, Joseph ;
Pusic, Andrea ;
Cordeiro, Peter ;
Shah, Jatin P. ;
Kraus, Dennis H. .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2013, 35 (11) :1567-1572
[6]   PERINEURAL INVASION IN SQUAMOUS-CELL SKIN CARCINOMA OF THE HEAD AND NECK [J].
GOEPFERT, H ;
DICHTEL, WJ ;
MEDINA, JE ;
LINDBERG, RD ;
LUNA, MD .
AMERICAN JOURNAL OF SURGERY, 1984, 148 (04) :542-547
[7]   Prognostic factors in pterygopalatine and infratemporal fossa malignant tumours: A single institution experience [J].
He, Yue ;
Yang, Huawei ;
Sun, Pan ;
Zhang, Chenping ;
Zhu, Hanguang ;
Liu, Zhonglong .
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 2015, 43 (04) :537-544
[8]   The endoscopic, endonasal, transmaxillary transpterygoid approach to the pterygopalatine fossa, infratemporal fossa, petrous apex, and the Meckel cave [J].
Hofstetter, Christoph P. ;
Singh, Ameet ;
Anand, Vijay K. ;
Kacker, Ashutosh ;
Schwartz, Theodore H. .
JOURNAL OF NEUROSURGERY, 2010, 113 (05) :967-974
[9]   Determination of perineural invasion preoperatively on radiographic images [J].
Lee, Kimberly J. ;
Abemayor, Elliot ;
Sayre, James ;
Bhuta, Sunita ;
Kirsch, Claudia .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2008, 139 (02) :275-280
[10]   Perineural Invasion in Cancer A Review of the Literature [J].
Liebig, Catherine ;
Ayala, Gustavo ;
Wilks, Jonathan A. ;
Berger, David H. ;
Albo, Daniel .
CANCER, 2009, 115 (15) :3379-3391
12