The interface between transcription and mechanisms maintaining genome integrity

被引：60

作者：

Svejstrup, Jesper Q. ^{[1
]}

机构：

[1] Canc Res UK London Res Inst, Clare Hall Labs, S Mimms EN6 3LD, Herts, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2010年 / 35卷 / 06期

关键词：

RNA-POLYMERASE-II; REPLICATION FORK PROGRESSION; NUCLEOTIDE EXCISION-REPAIR; DNA-DAMAGE; INDUCED UBIQUITINATION; ELONGATION; UBIQUITYLATION; RECOMBINATION; ACTIVATION; INITIATION;

D O I：

10.1016/j.tibs.2010.02.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Maintaining genome integrity is crucial for correctly regulated gene expression. Conversely, the process of transcription fundamentally impinges on genome stability, necessitating cellular mechanisms that lessen the genome destabilizing effect of reading genes. This review provides an overview of our present knowledge of how eukaryotic RNA polymerase II transcription affects, and is affected by, other DNA-related processes such as chromatin remodeling, DNA repair, recombination and replication.

引用

页码：333 / 338

页数：6

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