The long-term risk of lymphoma and skin cancer did not increase after topical calcineurin inhibitor use and phototherapy in a cohort of 25,694 patients with vitiligo

被引：24

作者：

Ju, Hyun Jeong ^{[1
]}

Han, Ju Hee ^{[1
]}

Kim, Min-Soo ^{[2
]}

Lee, Si-Hyung ^{[3
]}

Shin, Jung-Won ^{[4
]}

Choi, Mira ^{[5
]}

Jeong, Ki-Heon ^{[6
]}

Han, Tae Young ^{[7
]}

Choi, Chong Won ^{[8
]}

Lee, Hee Jung ^{[9
]}

Oh, Sang Ho ^{[10
,11
]}

Lee, Sang Hoon ^{[12
]}

Kim, Dong Hyun ^{[9
]}

Shin, Jeonghyun ^{[13
]}

Lee, Jong Hee ^{[14
]}

Kim, Sang Seok ^{[15
]}

Kang, Hee Young ^{[16
]}

Chang, Sung Eun ^{[17
]}

Kim, Jeong-Soo ^{[18
]}

Lee, Dong-Youn ^{[14
]}

Choi, Gwang Seong ^{[13
]}

Suh, Dae Hun ^{[3
]}

Kim, You Chan ^{[16
]}

Park, Chul Jong ^{[1
]}

Kim, Ki-Ho ^{[19
]}

Lee, Ai-Young ^{[20
]}

Park, Kyoung Chan ^{[4
]}

Lee, Mu-Hyoung ^{[6
]}

Bae, Jung Min ^{[1
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Dermatol, Seoul, South Korea

[2] Vet Hlth Serv Med Ctr, Dept Dermatol, Seoul, South Korea

[3] Seoul Natl Univ, Dept Dermatol, Coll Med, Seoul, South Korea

[4] Seoul Natl Univ, Dept Dermatol, Bundang Hosp, Seongnam, South Korea

[5] Inje Univ, Dept Dermatol, Ilsan Paik Hosp, Seoul, South Korea

[6] Kyung Hee Univ, Coll Med, Dept Dermatol, Seoul, South Korea

[7] Eulji Univ, Eulji Gen Hosp, Dept Dermatol, Seoul, South Korea

[8] Chungnam Natl Univ, Dept Dermatol, Sch Med, Daejeon, South Korea

[9] Cha Univ, Dept Dermatol, Sch Med, Bundang Cha Med Ctr, Seongnam, South Korea

[10] Yonsei Univ, Severance Hosp, Dept Dermatol, Coll Med, Seoul, South Korea

[11] Yonsei Univ, Coll Med, Cutaneous Biol Res Inst, Severance Hosp, Seoul, South Korea

[12] Soon Chun Hyang Univ Hosp, Dept Dermatol, Bucheon, South Korea

[13] Inha Univ, Dept Dermatol, Sch Med, Incheon, South Korea

[14] Sungkyunkwan Univ, Samsung Med Ctr, Dept Dermatol, Sch Med, Seoul, South Korea

[15] Hallym Univ, Kangdong Sacred Heart Hosp, Dept Dermatol, Coll Med, Seoul, South Korea

[16] Ajou Univ, Dept Dermatol, Sch Med, Suwon, South Korea

[17] Univ Ulsan, Asan Med Ctr, Dept Dermatol, Coll Med, Seoul, South Korea

[18] Hanyang Univ, Dept Dermatol, Coll Med, Seoul, South Korea

[19] Dong A Univ, Dept Dermatol, Sch Med, Busan, South Korea

[20] Dongkuk Univ, Grad Sch Med, Dept Dermatol, Ilsan Hosp, Goyang, South Korea

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2021年 / 84卷 / 06期

关键词：

actinic keratosis; excimer laser; lymphoma; melanoma; narrowband ultraviolet B; skin cancer; tacrolimus; vitiligo; ATOPIC-DERMATITIS; TACROLIMUS OINTMENT; PIMECROLIMUS; CORTICOSTEROIDS; GUIDELINES; EXPOSURE;

D O I：

10.1016/j.jaad.2021.01.067

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Topical calcineurin inhibitors have been used to treat vitiligo, either alone or in combination with phototherapy; however, the long-term safety of these agents remains controversial. Objective: To investigate the risk of lymphoma and skin cancer in vitiligo patients who received topical calcineurin inhibitors or phototherapy. Methods: A multicenter retrospective cohort study of 25,694 vitiligo patients who received topical calcineurin inhibitors or phototherapy for 6 weeks or more between 2001 and 2019 was performed. Cumulative doses of topical calcineurin inhibitors and total phototherapy sessions were determined. Outcomes were the development of lymphoma or skin cancer after enrollment, confirmed through chart review and pathology reports. Results: During 95,203 person-years, 13 cases of lymphoma, 22 of actinic keratosis, 15 of nonmelanoma skin cancer, and 5 of melanoma were observed. The risk of lymphoma and skin cancer was not significantly increased by topical calcineurin inhibitor dose or phototherapy sessions. The interaction between the topical calcineurin inhibitors and phototherapy was not associated with an increased risk of skin cancer. Limitations: Retrospective study, individual follow-up duration less than 4 years, and no adjustment for comorbidities and medication history. Not generalizable to other races. Conclusion: The long-term risk of skin cancer or lymphoma was not associated with the use of topical calcineurin inhibitors, phototherapy, and both treatments in combination in patients with vitiligo.

引用

页码：1619 / 1627

页数：9

共 4 条

[1] Long-Term Risk of Skin Cancer and Lymphoma in Users of Topical Tacrolimus and Pimecrolimus: Final Results from the Extension of the Cohort Study Protopic Joint European Longitudinal Lymphoma and Skin Cancer Evaluation (JOELLE)
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[2] Evaluation for Skin Cancer and Precancer in Patients With Vitiligo Treated With Long-term Narrowband UV-B Phototherapy
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[3] Risk of skin cancer in psoriasis patients receiving long-term narrowband ultraviolet phototherapy: Results from a Taiwanese population-based cohort study
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[4] Minimal risk of lymphoma and non-melanoma skin cancer despite long-term use of thiopurines in patients with inflammatory bowel disease: A longitudinal cohort analysis from northern India
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