Analysis of the relationship between insulin-like growth factor 1 receptor gene polymorphisms in Montbeliarde cows and the birth weight of their calves

Montbeliarde is a cattle breed of combined milk and meat performance type, which unlike the other breeds is characterized by several positive features, such as better health, high resistance to mastitis, calving ease and good weight gain. The study involved a population of 163 Montbeliarde cows. In view of the substantial role of the IGF-I/IGF-IR system in growth and development, the aim of this study was to show an association between insulin-like growth factor 1 receptor gene polymorphisms in Montbeliarde cows and birth weight of their offspring. Three single nucleotide polymorphisms within the IGF1R gene were analyzed using PCR-RFLP or ACRS-PCR methods. The frequencies of the most common genotypes were as follows: CC 0.90 (IGF1R/TaiI), GG 0.77 (IGF1R/MspI) and GG 0.58 (IGF1R/TaqI). A total of 14 combinations was compared, from which due to the low frequency (n < 10) only 4 were used for calculations. In the analysed herd, the mean body weight of calves regardless of the calving order was always the highest in animals with maternal CC / GG / AA combined genotype. This observation was confirmed statistically both for the individual genotypes as well as in the case of cows carrying such a combination at the same time (P < 0.01). Therefore, IGF1R may be considered as a promising candidate gene for the identification of molecular markers predicting meat quality in cattle.