Biomechanical, histological, and ultrastructural analyses of laser micro- and nano-structured titanium alloy implants: A study in rabbit

被引：66
作者：
Palmquist, Anders [1 ]
Lindberg, Fredrik [2 ]
Emanuelsson, Lena [1 ]
Branemark, Rickard [3 ]
Engqvist, Hakan [2 ]
Thomsen, Peter [1 ,4 ]
机构：
[1] Gothenburg Univ, Sahlgrenska Acad, Dept Biomat, Gothenburg, Sweden
[2] Uppsala Univ, Angstrom Lab, Dept Mat Sci, Uppsala, Sweden
[3] Sahlgrens Univ Hosp, Dept Orthopaed, Gothenburg, Sweden
[4] IBCT, Gothenburg, Sweden
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2010年 / 92A卷 / 04期
基金：
瑞典研究理事会;
关键词：
titanium alloy; laser; biomechanics; focused ion beam; TEM (transmission electron microscopy); interface; COMMERCIALLY PURE TITANIUM; ELECTRON-MICROSCOPIC ANALYSIS; SURFACE-ROUGHNESS; REMOVAL TORQUE; BONE RESPONSE; OXIDE-FILMS; INTERFACE; TI-6AL-4V; MORPHOLOGY;
D O I：
10.1002/jbm.a.32439
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The aim of this study was to evaluate the biomechanical properties and ultrastructure of the bone response of partly laser-modified Ti6Al4V implants compared with turned, machined implants after 8 weeks in rabbit. The surface analyses performed with interference microscopy and electron microscopy showed increased surface topography with micro- and nano-sized surface features as well as increased oxide thickness of the modified surface. The biomechanical testing demonstrated a 270% increase in torque value for the Surface modified implants compared with the control implants. Histological evaluation of ground sections of specimens subjected to biomechanical testing revealed ongoing bone formation and remodeling. A histological feature exclusively observed at the laser-modified surface was the presence of fracture in the mineralized bone rather than at the interface between the bone and implant. Transmission electron microscopy (TEM) was performed on Focused Ion Beam (FIB) prepared samples of the intact bone-implant interface, demonstrating a direct contact between nanocrystalline hydroxyapatite and the oxide of the laser-modified implant surface. In conclusion, laser-modified titanium alloy implants have significantly stronger bone anchorage compared with machined implants and show no adverse tissue reactions. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 92A: 1476-1486, 2010
引用
收藏
页码：1476 / 1486
页数：11
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