One-pot reduction of carboxylic acids via O-acylisoureas

被引：11

作者：

Herbert, JM

Hewson, AT

Peace, JE

机构：

[1] Sanofi Res, Dept Preclin Metab & Pharmacokinet, Isotope Chem Labs, Alnwick NE66 2JH, Northd, England

[2] Sheffield Hallam Univ, Div Chem, Sheffield S1 1WB, S Yorkshire, England

[3] Sheffield Hallam Univ, Hlth Res Inst, Sheffield S1 1WB, S Yorkshire, England

来源：

SYNTHETIC COMMUNICATIONS | 1998年 / 28卷 / 05期

关键词：

D O I：

10.1080/00032719808006479

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple one-pot reduction of aliphatic carboxylic acids to primary alcohols, by treatment with dicyclohexylcarbodiimide followed by lithium borohydride, is reported. The same methodology applied to aromatic carboxylic acids is shown to give a mixture of the alcohols with N-cyclohexylcarboxamides.

引用

页码：823 / 832

页数：10

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