Characterization of a Vivid Homolog in Botrytis cinerea

被引：5

作者：

Foley, Brandon J. ^{[1
]}

Stutts, Haley ^{[1
]}

Schmitt, Sydney L. ^{[1
]}

Lokhandwala, Jameela ^{[1
]}

Nagar, Aditi ^{[1
]}

Zoltowski, Brian D. ^{[1
]}

机构：

[1] Southern Methodist Univ, Ctr Drug Discovery Design & Delivery, Dept Chem, Dallas, TX 75205 USA

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 2018年 / 94卷 / 05期

关键词：

LOV DOMAIN PHOTORECEPTOR; LIGHT SENSOR; ARABIDOPSIS-THALIANA; PROTEIN-STRUCTURE; STRUCTURAL BASIS; PHOTOTROPIN; OXYGEN; PHOTOADAPTATION; NEUROSPORA; VIRULENCE;

D O I：

10.1111/php.12927

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Blue light-signaling pathways regulated by members of the light-oxygen-voltage (LOV) domain family integrate stress responses, circadian rhythms and pathogenesis in fungi. The canonical signaling mechanism involves two LOV-containing proteins that maintain homology to Neurospora crassa Vivid (NcVVD) and White Collar 1 (NcWC1). These proteins engage in homo- and heterodimerization events that modulate gene transcription in response to light. Here, we clone and characterize the VVD homolog in Botrytis cinerea (BcVVD). BcVVD retains divergent photocycle kinetics and is incapable of LOV mediated homodimerization, indicating modification of the classical hetero/homodimerization mechanism of photoadaptation in fungi.

引用

页码：985 / 993

页数：9

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