Oxidase-Like Fe-N-C Single-Atom Nanozymes for the Detection of Acetylcholinesterase Activity

被引：276

作者：

Wu, Yu ^{[1
]}

Jiao, Lei ^{[1
]}

Luo, Xin ^{[1
]}

Xu, Weiqing ^{[1
]}

Wei, Xiaoqian ^{[1
]}

Wang, Hengjia ^{[1
]}

Yan, Hongye ^{[1
]}

Gu, Wenling ^{[1
]}

Xu, Bo Z. ^{[2
]}

Du, Dan ^{[3
]}

Lin, Yuehe ^{[3
]}

Zhu, Chengzhou ^{[1
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticides & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China

[2] Univ Calif Berkeley, Dept Mat Sci & Engn, Berkeley, CA 94720 USA

[3] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA

来源：

SMALL | 2019年 / 15卷 / 43期

关键词：

acetylcholinesterase; biosensors; nanozymes; organophosphorus compounds; single-atom catalysts; CATALYST; CARBON; NANOCERIA;

D O I：

10.1002/smll.201903108

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Single-atom catalysts (SACs) have attracted extensive attention in the catalysis field because of their remarkable catalytic activity, gratifying stability, excellent selectivity, and 100% atom utilization. With atomically dispersed metal active sites, Fe-N-C SACs can mimic oxidase by activating O-2 into reactive oxygen species, O-2(-)center dot radicals. Taking advantages of this property, single-atom nanozymes (SAzymes) can become a great impetus to develop novel biosensors. Herein, the performance of Fe-N-C SACs as oxidase-like nanozymes is explored. Besides, the Fe-N-C SAzymes are applied in biosensor areas to evaluate the activity of acetylcholinesterase based on the inhibition toward nanozyme activity by thiols. Moreover, this SAzymes-based biosensor is further used for monitoring the amounts of organophosphorus compounds.

引用

页数：7

共 51 条

[1] High oxidase-mimic activity of Fe nanoparticles embedded in an N-rich porous carbon and their application for sensing of dopamine [J].

Chen, Qiumeng ;

Liang, Chunhong ;

Zhang, Xiaodan ;

Huang, Yuming .

TALANTA, 2018, 182 :476-483

[2] Fluorescent and colorimetric probes for detection of thiols [J].

Chen, Xiaoqiang ;

Zhou, Ying ;

Peng, Xiaojun ;

Yoon, Juyoung .

CHEMICAL SOCIETY REVIEWS, 2010, 39 (06) :2120-2135

[3] Single-Atom Catalysts: Synthetic Strategies and Electrochemical Applications [J].

Chen, Yuanjun ;

Ji, Shufang ;

Chen, Chen ;

Peng, Qing ;

Wang, Dingsheng ;

Li, Yadong .

JOULE, 2018, 2 (07) :1242-1264

[4] Rationally Modulate the Oxidase-like Activity of Nanoceria for Self Regulated Bioassays [J].

Cheng, Hanjun ;

Lin, Shichao ;

Muhammad, Faheem ;

Lin, Ying-Wu ;

Wei, Hui .

ACS SENSORS, 2016, 1 (11) :1336-1343

[5] Single-Atom Nanozyme Based on Nanoengineered Fe-N-C Catalyst with Superior Peroxidase-Like Activity for Ultrasensitive Bioassays [J].

Cheng, Nan ;

Li, Jin-Cheng ;

Liu, Dong ;

Lin, Yuehe ;

Du, Dan .

SMALL, 2019, 15 (48)

[6] Turning Au Nanoclusters Catalytically Active for Visible-Light-Driven CO2 Reduction through Bridging Ligands [J].

Cui, Xiaofeng ;

Wang, Jin ;

Liu, Bing ;

Ling, Shan ;

Long, Ran ;

Xiong, Yujie .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 140 (48) :16514-16520

[7] In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy [J].

Fan, Kelong ;

Xi, Juqun ;

Fan, Lei ;

Wang, Peixia ;

Zhu, Chunhua ;

Tang, Yan ;

Xu, Xiangdong ;

Liang, Minmin ;

Jiang, Bing ;

Yan, Xiyun ;

Gao, Lizeng .

NATURE COMMUNICATIONS, 2018, 9

[8] Porous Carbon-Hosted Atomically Dispersed Iron-Nitrogen Moiety as Enhanced Electrocatalysts for Oxygen Reduction Reaction in a Wide Range of pH [J].

Fu, Shaofang ;

Zhu, Chengzhou ;

Su, Dong ;

Song, Junhua ;

Yao, Siyu ;

Feng, Shuo ;

Engelhard, Mark H. ;

Du, Dan ;

Lin, Yuehe .

SMALL, 2018, 14 (12)

[9] Single Atom (Pd/Pt) Supported on Graphitic Carbon Nitride as an Efficient Photocatalyst for Visible-Light Reduction of Carbon Dioxide [J].

Gao, Guoping ;

Jiao, Yan ;

Waclawik, Eric R. ;

Du, Aijun .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 138 (19) :6292-6297

[10] Intrinsic peroxidase-like activity of ferromagnetic nanoparticles [J].

Gao, Lizeng ;

Zhuang, Jie ;

Nie, Leng ;

Zhang, Jinbin ;

Zhang, Yu ;

Gu, Ning ;

Wang, Taihong ;

Feng, Jing ;

Yang, Dongling ;

Perrett, Sarah ;

Yan, Xiyun .

NATURE NANOTECHNOLOGY, 2007, 2 (09) :577-583

← 1 2 3 4 5 6 →