Early viral complications following CD34-selected autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma

被引：37

作者：

Miyamoto, T

Gondo, H

Miyoshi, Y

Shigematsu, H

Minematsu, T

Takenaka, K

Tanimoto, K

Horiuchi, T

Asano, Y

Inaba, S

Minamishima, Y

Niho, Y

机构：

[1] Kyushu Univ, Fac Med, Blood Transfus Serv, Fukuoka 812, Japan

[2] Kyushu Univ, Fac Med, Dept Internal Med 1, Fukuoka 812, Japan

[3] Miyazaki Med Coll, Dept Microbiol, Miyazaki 88916, Japan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1998年 / 100卷 / 02期

关键词：

CD34(+) cells; stem cell transplantation; immunodeficiency; viral infection;

D O I：

10.1046/j.1365-2141.1998.00572.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A patient with non-Hodgkin's lymphoma who received a CD34-selected autologous peripheral blood stem cell transplant (PBSCT) developed cytomegalovirus retinitis, adenovirus-associated haemorrhagic cystitis (HC) and fatal herpes simplex virus pneumonia. Depletion of mature T cells from the graft and a persistent decrease in CD4(+) lymphocytes following PBSCT may have predisposed this patient to such viral infections. Infusion of cryopreserved autologous PBSC (containing mature T cells) was effective for adenovirus-associated HC. Immunosuppression and resultant viral infections may affect patients receiving CD34-selected autologous transplantation.

引用

页码：348 / 350

页数：3

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