Evidence of vertical transmission of SARS-CoV-2 and interstitial pneumonia in second-trimester twin stillbirth in asymptomatic woman. Case report and review of the literature

被引：10

作者：

Patane, Luisa ^{[1
]}

Cadamuro, Massimiliano

Massazza, Gabriella

Pirola, Serena

Stagnati, Valentina

Comerio, Chiara

Carnelli, Marco

Arosio, Marco

Callegaro, Anna Paola

Tebaldi, Paola

Rigoli, Elena

Gianatti, Andrea

Morotti, Denise

机构：

[1] ASST Papa Giovanni XXIII, Dept Obstet & Gynecol, Bergamo, Italy

来源：

AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM | 2022年 / 4卷 / 03期

关键词：

D O I：

10.1016/j.ajogmf.2022.100589

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Data on the vertical transmission rate of COVID-19 in pregnancy are limited, although data reporting mother-fetal transmission in the second trimester of pregnancy are controversial. We described a case of second-trimester twin stillbirth in a woman with SARS-CoV-2 infection in which placental and fetal markers of infection were detected, despite the absence of respiratory syndrome. The patient developed clinical chorioamnionitis and spontaneously delivered 2 stillborn infants. Placental histology and immunohistochemistry demonstrated SARS-CoV-2 infection mostly within the syncytiotrophoblast, and fetal autopsy showed the development of interstitial pneumonia. Our findings demonstrated that in utero vertical transmission is possible in asymptomatic pregnant women with SARS-CoV-2 infection and that infection can lead to severe morbidity in the second trimester of pregnancy.

引用

页数：5

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