Collecting Duct Renin: A Critical Link in Angiotensin II-Dependent Hypertension

被引：6

作者：

Prieto, Minolfa C. ^{[1
]}

Navar, L. Gabriel ^{[1
]}

机构：

[1] Tulane Univ, Hlth Sci Ctr, Dept Physiol, New Orleans, LA 70112 USA

来源：

LOCAL CARDIAC RENIN-ANGIOTENSIN ALDOSTERONE SYSTEM, SECOND EDITION | 2009年

基金：

美国国家卫生研究院;

关键词：

CONVERTING-ENZYME; ANG-II; TUBULAR FLUID; RENAL ENDOSOMES; MESSENGER-RNA; EXPRESSION; KIDNEY; RECEPTOR; 2-KIDNEY; AUGMENTATION;

D O I：

10.1007/978-1-4419-0528-4_13

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

All of the components needed for angiotensin II generation are present within the renal tubular network of the kidney. This brief review is focused oil recent evidence demonstrating that inappropriate activation of renin in distal nephron segments by acting on angiotensinogen generated in the proximal tubule cells and delivered to the distal nephron may contribute to increased distal intrarenal angiotensin II formation, sodium retention, and development and progression of hypertension. Moreover, mechanisms regulating collecting duct renin during Ang II-dependent hypertension are discussed.

引用

页码：133 / +

页数：4

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