Protein phosphatase 2A: Its structure, function and activity regulation

被引：0
|
作者：
Liu, WJ [1 ]
Shen, Y [1 ]
Ding, J [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Div Anti Tumor Pharmacol, State Key Lab Drug Res,Inst Mat Med, Shanghai 200031, Peoples R China
来源：
ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2003年 / 35卷 / 02期
关键词：
protein phosphatase 2A(PP2A); holoenzyme complex; core dimer enzyme;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Protein phosphatase 2A ( PP2A) is a major kind of serine/threonine protein phosphatase in eukaryotic cells. PP2A has many subunits and isozymes encoded by different genes to form many different PP2A holo-enzymes. PP2A play important roles in regulation of cell cycle, signal transduction, cell differentiation, and transformation. Its activity is related to several diseases, including neurodegenerative diseases and cancer. The regulation of PP2A activity is accomplished by its subunits' expression, cellular localization, phosphorylation and methylation. The second messenger, ceramide, also plays an important role in the regulation of PP2A activity, as well as a plenty of low molecular mass inhibitors of PP2A and other protein phosphatases.
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页码：105 / 112
页数：8
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