Exploiting Copper Redox for 19F Magnetic Resonance-Based Detection of Cellular Hypoxia

被引：80

作者：

Xie, Da ^{[1
]}

King, Tyler L. ^{[1
]}

Banerjee, Arnab ^{[1
]}

Kohli, Vikraant ^{[1
]}

Que, Emily L. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Chem, 105 E 24th St Stop A5300, Austin, TX 78712 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 09期

关键词：

MRI CONTRAST AGENT; IMAGING TUMOR HYPOXIA; IN-VIVO; BIS(THIOSEMICARBAZONATO) COMPLEXES; PROTEASE ACTIVITY; PROBE; SELECTIVITY; MECHANISM; CELLS; RADIOPHARMACEUTICALS;

D O I：

10.1021/jacs.5b13215

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a pair of fluorinated, redox-active copper complexes for potential use as F-19 MRI contrast agents for detecting cellular hypoxia. Trifluorinated Cu(II) ATSM-F-3 displays the appropriate redox potential for selective accumulation in hypoxic cells and a completely quenched F-19 NMR signal that is "turned on" following reduction to Cu(I). Incubation of cancer cells with CuATSM-F-3 resulted in a selective detection of F-19 signal in cells grown under hypoxic conditions.

引用

页码：2937 / 2940

页数：4

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