Posterior Reversible Encephalopathy Syndrome in infants and young children

被引：9

作者：

Cordelli, Duccio Maria ^{[1
]}

Marra, Chiara ^{[1
]}

Ciampoli, Lara ^{[1
]}

Barbon, Davide ^{[1
]}

Toni, Francesco ^{[2
]}

Zama, Daniele ^{[3
]}

Giordano, Lucio ^{[4
]}

Milito, Giuseppe ^{[4
]}

Sartori, Stefano ^{[5
,6
]}

Sainati, Laura ^{[7
]}

Foiadelli, Thomas ^{[8
]}

Mina, Tommaso ^{[9
]}

Fusco, Lucia ^{[10
]}

Santarone, Marta ^{[10
]}

Iurato, Chiara ^{[11
]}

Orsini, Alessandro ^{[12
]}

Farello, Giovanni ^{[13
]}

Verrotti, Alberto ^{[14
]}

Aceti, Arianna ^{[14
]}

Masetti, Riccardo ^{[3
]}

机构：

[1] Univ Bologna, S Orsola Hosp, Dept Med & Surg Sci DIMEC, Unit Child Neurol & Psychiat, Via Massarenti 11, I-40138 Bologna, Italy

[2] UOC Neuroradiol, IRCCS Ist Sci Neurol Bologna, Bologna, Italy

[3] Univ Bologna, St Orsola Hosp, Dept Pediat, Unit Pediat Oncol & Haematol Lalla Seragnoli, Bologna, Italy

[4] Spedali Civil Brescia, Child Neurol & Psychiat Unit, Brescia, Italy

[5] Univ Hosp Padua, Dept Womens & Childrens Hlth, Pediat Neurol & Neurophysiol Unit, Padua, Italy

[6] Pediat Res Inst Citta Della Speranza, Neuroimmunol Grp, Padua, Italy

[7] Azienda Osped Univ Padova, Dept Womans & Child Hlth, Clin Pediat Hematol Oncol, Padua, Italy

[8] Univ Pavia, Fdn IRCCS Policlin San Matteo, Pediat Clin, Pavia, Italy

[9] Fdn IRCCS Policlin San Matteo, Oncoematol Pediat, Pavia, Italy

[10] Bambino Gesu Pediat Hosp, Dept Neurosci, Rome, Italy

[11] Univ Pisa, Dept Clin & Expt Med, Paediat Unit, Pisa, Italy

[12] Univ Hosp Pisa, Dept Paediat, Paediat Neurol, Pisa, Italy

[13] Univ Perugia, Dept Pediat, Perugia, Italy

[14] Univ Bologna, Dept Med & Surg Sci, Neonatal Intens Care Unit, AOU Bologna, Bologna, Italy

来源：

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY | 2021年 / 30卷

关键词：

PRES; Status epilepticus; Seizures; Infants; EEG monitoring; ICU admission; HEMATOPOIETIC STEM-CELL; PRES;

D O I：

10.1016/j.ejpn.2020.10.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aim: The aim of this study was to describe the characteristics of Posterior Reversible Encephalopathy Syndrome (PRES) in infants and young children (<6 years) and to compare them with the older pediatric population affected by PRES. Methods: we retrospectively reviewed records of 111 children (0-17 years) diagnosed with PRES from 2000 to 2018 in 6 referral pediatric hospitals in Italy. The clinical, radiological and EEG features, as well as intensive care unit (ICU) admission rate and outcome of children aged <6 years were compared to those of older children (6-17 years). Factors associated with ICU admission in the whole pediatric cohort with PRES were also evaluated. Results: Twenty-nine patients younger than 6 years (26%) were enrolled with a median age at onset of PRES of 4 years (range: 6 months-5 years). Epileptic seizures were the most frequent presentation at the disease onset (27/29 patients). Status epilepticus (SE) was observed in 21/29 patients: in detail, 11 developed convulsive SE and 10 presented nonconvulsive SE (NCSE). SE was more frequent in children <6 years compared with older children (72% vs 45%) as well as NCSE (35% vs 10%). Seventeen children aged <6 years required ICU admission. Prevalence of ICU admissions was higher within younger population compared to older (59% vs 37%). In the whole study population SE was significantly associated with ICU admission (p 1/4 0.001).

引用

页码：128 / 133

页数：6

共 18 条

[1] Posterior Reversible Encephalopathy Syndrome Associated with Hemorrhage [J].