Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors

被引：35

作者：

Mendes-da-Cruz, Daniella Areas ^{[1
,2
]}

Brignier, Anne Colette ^{[1
,3
]}

Asnafi, Vahid ^{[4
]}

Baleydier, Frederic ^{[4
]}

Messias, Carolina Valenca ^{[2
]}

Lepelletier, Yves ^{[1
,5
]}

Bedjaoui, Nawel ^{[4
]}

Renand, Amedee ^{[1
]}

Smaniotto, Salete ^{[6
]}

Canioni, Danielle ^{[4
,6
]}

Milpied, Pierre ^{[1
]}

Balabanian, Karl ^{[7
]}

Bousso, Philippe ^{[8
]}

Lepretre, Stephane ^{[9
]}

Bertrand, Yves ^{[10
]}

Dombret, Herve ^{[11
,12
]}

Ifrah, Norbert ^{[13
,14
]}

Dardenne, Mireille ^{[1
]}

Macintyre, Elizabeth ^{[4
]}

Savino, Wilson ^{[2
]}

Hermine, Olivier ^{[1
,4
,5
]}

机构：

[1] Paris Descartes Univ, CNRS UMR8147, Paris, France

[2] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Rio De Janeiro, Brazil

[3] Necker Childrens Hosp, AP HP, Dept Clin Hematol, Paris, France

[4] Necker Childrens Hosp, AP HP, Lab Oncohematol, INSERM U1151, Paris, France

[5] Imagine Inst, INSERM U1163, CNRS ERL 8254, Lab Cellular & Mol Basis Hematol Disorders & Thei, Paris, France

[6] Univ Fed Alagoas, Dept Morphol, Maceio, Brazil

[7] Inst Pasteur, INSERM U819, Paris, France

[8] Inst Pasteur, INSERM U668, Paris, France

[9] Ctr Henri Becquerel, Dept Hematol, F-76038 Rouen, France

[10] Hop Debrousse, Serv Pediat Hematol, Lyon, France

[11] Univ Paris 07, Hop St Louis, AP HP, Paris, France

[12] Univ Paris 07, Inst Univ Hematol EA3518, Paris, France

[13] Ctr Hosp Univ Nantes, Univ Angers, Serv Malad, Pole Rech & Enseignement Super, Angers, France

[14] INSERM U892, Angers, France

来源：

PLOS ONE | 2014年 / 9卷 / 07期

关键词：

SPHINGOSINE 1-PHOSPHATE RECEPTOR; ACUTE LYMPHOBLASTIC-LEUKEMIA; HUMAN THYMOCYTE MIGRATION; LYMPHOCYTE EGRESS; THYMUS; EXPRESSION; EMIGRATION; CHEMOKINE; GRADIENTS; TISSUES;

D O I：

10.1371/journal.pone.0103405

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we describe the expression and role of semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) in human T cell precursors. NRP2 and SEMA3F are expressed in the human thymus, in both lymphoid and non-lymphoid compartments. SEMA3F have a repulsive effect on thymocyte migration and inhibited CXCL12- and sphingosine-1-phosphate (S1P)-induced thymocyte migration by inhibiting cytoskeleton reorganization prior to stimuli. Moreover, NRP2 and SEMA3F are expressed in human T-cell acute lymphoblastic leukemia/lymphoma primary cells. In these tumor cells, SEMA3F also blocks their migration induced by CXCL12 and S1P. Our data show that SEMA3F and NRP2 are further regulators of human thymocyte migration in physiological and pathological conditions.

引用

页数：7

共 30 条

[1] Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration [J].

Allende, ML ;

Dreier, JL ;

Mandala, S ;

Proia, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (15) :15396-15401

[2] Chemokines and lymphopoiesis in human thymus [J].

Annunziato, F ;

Romagnani, P ;

Cosmi, L ;

Lazzeri, E ;

Romagnani, S .

TRENDS IN IMMUNOLOGY, 2001, 22 (05) :277-281

[3]

Atwal JK, 2003, J NEUROSCI, V23, P7602

[4] A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding [J].

Chalasani, SH ;

Sabelko, KA ;

Sunshine, MJ ;

Littman, DR ;

Raper, JA .

JOURNAL OF NEUROSCIENCE, 2003, 23 (04) :1360-1371

[5]

Chiba K, 2006, CELL MOL IMMUNOL, V3, P11

[6] High expression of the chemokine receptor CXCR4 predicts extramedullary organ infiltration in childhood acute lymphoblastic leukaemia [J].

Crazzolara, R ;

Kreczy, A ;

Mann, G ;

Heitger, A ;

Eibl, G ;

Fink, FM ;

Möhle, R ;

Meister, B .

BRITISH JOURNAL OF HAEMATOLOGY, 2001, 115 (03) :545-553

[7]

CRIST WM, 1988, BLOOD, V72, P1891

[8] Role of semaphorins in the adult nervous system [J].

de Wit, J ;

Verhaagen, J .

PROGRESS IN NEUROBIOLOGY, 2003, 71 (2-3) :249-267

[9] How to find your way through the thymus: a practical guide for aspiring T cells [J].

Dzhagalov, Ivan ;

Phee, Hyewon .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2012, 69 (05) :663-682

[10] The role of neuropilins in cancer [J].

Ellis, LM .

MOLECULAR CANCER THERAPEUTICS, 2006, 5 (05) :1099-1107

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