The role of RNA interference in heterochromatic silencing

被引：397
作者：
Lippman, Z
Martienssen, R
机构：
[1] Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
[2] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
来源：
NATURE | 2004年 / 431卷 / 7006期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
D O I：
10.1038/nature02875
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Soon after its discovery 75 years ago, heterochromatin, a dense chromosomal material, was found to silence genes. But its importance in regulating gene expression was controversial. Long thought to be inert, heterochromatin is now known to give rise to small RNAs, which, by means of RNA interference, direct the modification of proteins and DNA in heterochromatic repeats and transposable elements. Heterochromatin has thus emerged as a key factor in epigenetic regulation of gene expression, chromosome behaviour and evolution.
引用
收藏
页码：364 / 370
页数：7
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