S-217622, a 3CL Protease Inhibitor and Clinical Candidate for SARSCoV-2

被引：90

作者：

Tyndall, Joel D. A. ^{[1
]}

机构：

[1] Univ Otago, Sch Pharm, Dunedin 9054, New Zealand

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2022年 / 65卷 / 09期

关键词：

D O I：

10.1021/acs.jmedchem.2c00624

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The coronavirus disease (COVID-19) pandemic has highlighted the ability of scientists to quickly react to the immense challenge presented to the world. The orally available 3CL protease inhibitor S-217622 is currently progressing through clinical trials and its discovery via structure-based drug design, screening and optimization by Shionogi and Hokkaido University is presented here.

引用

页码：6496 / 6498

页数：3

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