A role for fucoseα(1-2)galactose carbohydrates in neuronal growth

被引：55
|
作者：
Kalovidouris, SA [1 ]
Gama, CI [1 ]
Lee, LW [1 ]
Hsieh-Wilson, LC [1 ]
机构：
[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 05期
关键词：
D O I：
10.1021/ja044631v
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a fucose α(1-2) galactose-mediated pathway for the modulation of neuronal growth and morphology. Our studies provide strong evidence for the presence of Fucα(1-2)Gal glycoproteins and lectin receptors in hippocampal neurons. Additionally, we show that manipulation of Fucα(1-2)Gal-associated proteins using small-molecule and lectin probes induces dramatic changes in neuronal morphology. These findings may provide a novel pathway to stimulate neuronal growth and regeneration. Copyright © 2005 American Chemical Society.
引用
收藏
页码：1340 / 1341
页数：2
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