Bisabolane type sesquiterpenes from a marine Didiscus sponge

被引：1
|
作者：
Tasdemir, D [1 ]
Bugni, TS
Mangalindan, GC
Concepción, GP
Harper, MK
Ireland, DM
机构：
[1] Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey
[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA
[3] Univ Philippines, Inst Marine Sci, Quezon City 1101, Philippines
来源：
TURKISH JOURNAL OF CHEMISTRY | 2003年 / 27卷 / 02期
关键词：
marine sponge; Didiscus; (+)-curcuphenol; (+)-curcudiol; beta-sitosterol; phenethylamine; HCT-116;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two bisabolane type sesquiterpene phenols, (+)-curcuphenol (1) and (+)-curcudiol (2), were isolated from a Philippine marine sponge, Didiscus sp., in addition to beta-sitosterol (3) and phenethylamine (4). The structures of the metabolites were established on the basis of spectral evidence (1D- and 2D NMR [alpha](D), EIMS). (+)-Curcuphenol (1) showed cytotoxicity, which is indicative of a p53 independent mechanism.
引用
收藏
页码：273 / 279
页数：7
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