Bisabolane type sesquiterpenes from a marine Didiscus sponge

被引：1

作者：

Tasdemir, D ^{[1
]}

Bugni, TS

Mangalindan, GC

Concepción, GP

Harper, MK

Ireland, DM

机构：

[1] Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey

[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

[3] Univ Philippines, Inst Marine Sci, Quezon City 1101, Philippines

来源：

TURKISH JOURNAL OF CHEMISTRY | 2003年 / 27卷 / 02期

关键词：

marine sponge; Didiscus; (+)-curcuphenol; (+)-curcudiol; beta-sitosterol; phenethylamine; HCT-116;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two bisabolane type sesquiterpene phenols, (+)-curcuphenol (1) and (+)-curcudiol (2), were isolated from a Philippine marine sponge, Didiscus sp., in addition to beta-sitosterol (3) and phenethylamine (4). The structures of the metabolites were established on the basis of spectral evidence (1D- and 2D NMR [alpha](D), EIMS). (+)-Curcuphenol (1) showed cytotoxicity, which is indicative of a p53 independent mechanism.

引用

页码：273 / 279

页数：7

共 24 条

[1] NATURALLY OCCURRING TERPENE DERIVATIVES .117. NEW SANDARACOPIMARDIENE DERIVATIVES, SESQUITERPENES, AND SESQUITERPENE LACTONES FROM ZEXMENIA SPECIES [J].

BOHLMANN, F ;

LONITZ, M .

CHEMISCHE BERICHTE-RECUEIL, 1978, 111 (03) :843-852

[2] SPONGE SECONDARY METABOLITES - NEW RESULTS [J].

BRAEKMAN, JC ;

DALOZE, D ;

MOUSSIAUX, B ;

STOLLER, C ;

DENEUBOURG, F .

PURE AND APPLIED CHEMISTRY, 1989, 61 (03) :509-512

[3] Disruption of p53 in human cancer cells alters the responses to therapeutic agents [J].

Bunz, F ;

Hwang, PM ;

Torrance, C ;

Waldman, T ;

Zhang, YG ;

Dillehay, L ;

Williams, J ;

Lengauer, C ;

Kinzler, KW ;

Vogelstein, B .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (03) :263-269

[4] Requirement for p53 and p21 to sustain G2 arrest after DNA damage [J].

Bunz, F ;

Dutriaux, A ;

Lengauer, C ;

Waldman, T ;

Zhou, S ;

Brown, JP ;

Sedivy, JM ;

Kinzler, KW ;

Vogelstein, B .

SCIENCE, 1998, 282 (5393) :1497-1501

[5]

CATALAN C A N, 1989, Flavour and Fragrance Journal, V4, P25, DOI 10.1002/ffj.2730040106

[6] An unusual sesquiterpene derivative from the Caribbean gorgonian Pseudopterogoriga rigida [J].

D'Armas, HT ;

Mootoo, BS ;

Reynolds, WF .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (11) :1593-1595

[7]

DUQUE C, 1988, REV COLOMB QUIM, V17, P39

[8] Rigidone, a sesquiterpene o-quinone from the gorgonian Pseudopterogorgia rigida [J].

Freyer, AJ ;

Patil, AD ;

Killmer, L ;

Zuber, G ;

Myers, C ;

Johnson, RK .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (03) :309-311

[9] (+)-CURCUPHENOL AND DEHYDROCURCUPHENOL, NOVEL SESQUITERPENES WHICH INHIBIT H,K-ATPASE, FROM A MARINE SPONGE EPIPOLASIS SP [J].

FUSETANI, N ;

SUGANO, M ;

MATSUNAGA, S ;

HASHIMOTO, K .

EXPERIENTIA, 1987, 43 (11-12) :1234-1235

[10]

HASHIMOTO T, 1987, Patent No. 19870318

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