Aiming for the Ideal Synthesis

被引：519

作者：

Gaich, Tanja ^{[1
]}

Baran, Phil S. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 14期

基金：

奥地利科学基金会;

关键词：

BIOMIMETIC TOTAL-SYNTHESIS; DIELS-ALDER REACTIONS; ENANTIOSELECTIVE TOTAL-SYNTHESIS; MARINE ALKALOIDS HAPALINDOLES; PYRROLE-IMIDAZOLE ALKALOIDS; COMPLEX BRIDGED ALKALOIDS; FORMAL TOTAL-SYNTHESIS; BETA-LACTAM ALKALOIDS; 1ST TOTAL-SYNTHESIS; RING-SYSTEM;

D O I：

10.1021/jo1006812

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The field of total synthesis has a rich history and a vibrant future. Landmark advances and revolutionary strides in the logic of synthesis have put the practicing chemist in the enviable position of being able to create nearly any molecule with enough time and effort. The stage is now set for organic chemists to aim for "ideality" in the way molecules are synthesized. This perspective presents a simple and informative definition of "ideality" and demonstrates its use during the self-evaluation of several syntheses from our laboratory.

引用

页码：4657 / 4673

页数：17

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