Chemical Composition, Antimicrobial, and Cytotoxic Activities of the Essential Oil of Otostegia fruticosa subsp schimperi from Yemen

被引：0
|
作者：
Ali, Nasser A. Awadh [1 ]
Alhamzy, Ebtesam Hasan [2 ]
Chhetri, Bhuwan K. [3 ]
Dosoky, Noura S. [3 ]
Setzer, William N. [3 ]
机构：
[1] Albaha Univ, Fac Clin Pharm, Dept Pharmacognosy, POB 1988, Albaha, Saudi Arabia
[2] Sanaa Univ, Fac Sci, Dept Biol, POB 13499, Sanaa, Yemen
[3] Univ Alabama Huntsville, Dept Chem, Huntsville, AL 35899 USA
来源：
NATURAL PRODUCT COMMUNICATIONS | 2017年 / 12卷 / 06期
关键词：
Essential oil; Chemical composition; Otostegia fruticosa schimperi; Yemen; Antimicrobial; Cytotoxicity; ANTIOXIDANT; MONTEVERDE; PLANTS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The leaf essential oil of Otostegia fruticosa subsp. schimperi (Lamiaceae) was obtained by hydrodistillation and analyzed by gas chromatography - mass spectrometry (GC-MS). The major components in the leaf oil were r-cadinol (9.3%), beta-caryophyllene (8.8%), and bornyl formate (5.2%) as well as two unidentified diterpenoids (12.7% and 9.4%, respectively). The leaf oil was screened for antibacterial (Bacillus cereus, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), antifungal (Aspergillus niger, Candida albicans, and Botrytis cinerea), and cytotoxic (MCF-7 and MDA-MB-231) activity. The oil did not show antimicrobial or antifungal activity, but it showed very good cytotoxicity against MCF-7 (IC50 = 55.1 mu g/mL) and MDA-MB-231 (IC50 = 70.3 mu g/mL) cell lines.
引用
收藏
页码：969 / 972
页数：4
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